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Observational studies that compared serum DHEA levels between women with AN and healthy controls were included for meta\u2010analysis, and randomized controlled trials (RCTs) that evaluated the effects of DHEA supplementation on bone mass were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meta\u2010analysis of 15 cross\u2010sectional studies revealed that patients with AN had significantly elevated serum DHEA levels (mean difference (MD)\u00a0=\u00a0311.63\u2009ng\/dl; 95% confidence interval (CI), 78.01\u2013545.25) and reduced DHEAS levels (MD\u00a0=\u00a0\u221224.90\u2009\u03bcg\/dl; 95% CI, \u221241.72 to \u22128.07) compared with healthy controls. A systematic review of seven RCTs found that DHEA monotherapy does not improve bone mineral density (BMD) compared with placebo after adjusting for weight gain. While the combination of DHEA and conjugated oral contraceptives has led to increased bone strength and decreased bone loss, the beneficial effect appears to be limited to older adolescents and adults with closed physes. Potential detrimental effects on BMD were identified in younger adolescents with open physes in one study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Due to the lack of apparent benefit of DHEA in women with AN and its potential detrimental effect on BMD in young patients with AN, current evidence does not support the use of DHEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance<\/jats:title><jats:p>This study demonstrates that women with anorexia nervosa have abnormal levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), which have been suggested by previous studies to play a role in the development of low bone density in this condition. However, current evidence does not support the use of DHEA as a treatment to preserve bone health in patients with anorexia nervosa given the lack of clear benefit following its use and also because of a potential detrimental effect on bone mineral density in young patients with anorexia nervosa.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23714","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T05:16:57Z","timestamp":1650691017000},"page":"733-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"55","author":[{"given":"James","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine Taipei Medical University  Taipei 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