{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:38:06Z","timestamp":1789706286455,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Anorexia nervosa (AN) is a devastating disorder with evidence of underexplored heritability. Twin and family studies estimate heritability (<jats:italic>h<\/jats:italic><jats:sup>2<\/jats:sup>) to be 57%\u201364%, and genome\u2010wide association studies (GWAS) reveal significant genetic correlations with psychiatric and anthropometric traits and a total of nine genome\u2010wide significant loci. Whether significantly associated single\u00a0nucleotide polymorphisms identified by GWAS are causal or tag true causal variants, remains to be elucidated. We propose a novel method for bridging this knowledge gap by fine\u2010mapping short structural variants (SSVs) in and around GWAS\u2010identified loci. SSV fine\u2010mapping of loci associated with complex disorders such as schizophrenia, amyotrophic lateral sclerosis, and Alzheimer's disease has uncovered genetic risk markers, phenotypic variability between patients, new pathological mechanisms, and potential therapeutic targets. We analyze previous investigations' methods and propose utilizing an evaluation algorithm to prioritize 10 SSVs for each of the top two AN GWAS\u2010identified loci followed by Sanger sequencing and fragment analysis via capillary electrophoresis to characterize these SSVs for case\/control association studies. Success of previous SSV analyses in complex disorders and effective utilization of similar methodologies supports our proposed method. Furthermore, the structural and spatial properties of the 10 SSVs identified for each of the top two AN GWAS\u2010associated loci, cell adhesion molecule 1 (<jats:italic>CADM1<\/jats:italic>) and NCK\u00a0interacting protein with SH3 domain (<jats:italic>NCKIPSD<\/jats:italic>), are similar to previous studies. We propose SSV fine\u2010mapping of AN\u2010associated loci will identify causal genetic architecture. Deepening understandings of AN may lead to novel therapeutic targets and subsequently increase quality\u2010of\u2010life for individuals living with the illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance Statement<\/jats:title><jats:p>Anorexia nervosa is a severe and complex illness, arising from a combination of environmental and genetic factors. Recent studies estimate the contribution of genetic variability; however, the specific DNA sequences and how they contribute remain unknown. We present a novel approach, arguing that the genetic variant class, short structural variants, could answer this knowledge gap and allow development of biologically targeted therapeutics, improving quality\u2010of\u2010life and patient outcomes for affected individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23716","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T08:14:17Z","timestamp":1650960857000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bridging the gap: Short structural variants in the genetics of anorexia nervosa"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-3353","authenticated-orcid":false,"given":"Natasha","family":"Berthold","sequence":"first","affiliation":[{"name":"School of Nursing, Midwifery, Health Sciences &amp; Physiotherapy University of Notre Dame Australia  Fremantle Western Australia 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