{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:50:27Z","timestamp":1791312627420,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32MH015330"],"award-info":[{"award-number":["T32MH015330"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>As patients with anorexia nervosa tend to \u201clike\u201d palatable tastants less than controls, we set out to model this preclinically by using the taste reactivity test (TRT) to assess hedonic state in rats following weight restoration from a bout of activity\u2010based anorexia (ABA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Female rats (<jats:italic>n<\/jats:italic>\u00a0=\u200931) were surgically implanted with an intraoral catheter, which allowed experimenters to assess baseline TRT to six tastants. Following baseline TRT, animals were either exposed to the activity\u2010based anorexia condition (ABA; 1.5HR chow\/ad lib wheel until 25% weight loss), kept sedentary (SED; ad lib chow\/locked wheel), given access to running wheels with ad lib chow access (RW; ad lib chow\/wheel), or were body weight matched to the ABA group (BWM; restricted chow\/locked wheel). Following 25% weight loss, wheels were locked and food returned to ABA rats. Paired RW groups had their wheels locked and paired BWM rats were given ad lib access to food. Animals were given 10\u2009days to recover prior to a second TRT. Videos were analyzed for liking (tongue protrusions) and disliking (gape) behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ABA group displayed a significant within\u2010subject reduction in cumulative lick responses to water and 1\u00a0M sucrose. Additionally, we found the SED and ABA group displayed a significant within\u2010subject reduction in cumulative lick responses to .1\u00a0M sucrose. Positive hedonic responses did not decline in either the BWM or the RW groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The data show a novel phenomenon that a history of ABA results in an anhedonia phenotype that mirrors aspects of AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance statement<\/jats:title><jats:p>Patients recovered from anorexia nervosa report anhedonia, or the lack of pleasure in consuming palatable foods. Unfortunately, the biological mechanism underpinning anhedonia in anorexia nervosa is not well understood. The current study assessed hedonic state in adolescent female rats prior to and 10\u2009days recovered following the activity\u2010based anorexia paradigm. Age\u2010matched, running wheel\u2010matched and body weight\u2010matched control groups were also tested at the same time points.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23752","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T11:59:21Z","timestamp":1654948761000},"page":"1042-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adolescent female rats recovered from the activity\u2010based anorexia display blunted hedonic responding"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-0767","authenticated-orcid":false,"given":"Matthew M.","family":"Hurley","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf N.","family":"Nawari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; 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