{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:57:40Z","timestamp":1792144660887,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH096777"],"award-info":[{"award-number":["MH096777"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH103436"],"award-info":[{"award-number":["MH103436"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Anorexia nervosa (AN) is a severe psychiatric illness with complex etiology. Recently, we found elevated striatal brain response to sweet taste stimuli in adolescents and young adults with AN. Here, we tested the hypothesis that nutritional rehabilitation normalizes prediction error activation, a measure for dopamine\u2010related reward circuit response, to salient caloric taste stimuli in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 28 individuals with AN (age\u00a0=\u00a016\u2009\u00b1\u20092\u2009years; body mass index [BMI]\u00a0=\u00a016\u2009\u00b1\u20091) who previously underwent brain imaging while performing a taste prediction error task using sucrose as salient caloric stimulus, participated in a second brain imaging scan (BMI\u00a0=\u00a018\u2009\u00b1\u20091) after intensive specialized eating disorder treatment (41\u2009\u00b1\u200915\u2009days). A total of 31 healthy controls (age\u00a0=\u00a016\u2009\u00b1\u20093\u2009years; BMI\u00a0=\u00a021\u2009\u00b1\u20092) were also studied on two occasions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, individuals with AN demonstrated an elevated salience response in bilateral caudate head and nucleus accumbens, and right ventral striatum. At the second scan, elevated response was only found in the right nucleus accumbens. A moderator analysis indicated that greater increase in BMI and greater decrease in sweetness perception predicted lesser prediction error response at the second scan in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consistent with the previously reported monetary stimulus\u2013response, elevated taste prediction error response in AN was largely absent after weight restoration. This study indicates that changes in BMI and sweet taste perception are independent moderators of change of brain salience response in adolescents and young adults with AN. The study points toward dynamic changes in the brain reward circuitry in AN and highlights the importance of nutrition and weight restoration in that process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance Statement<\/jats:title><jats:p>AN is a severe psychiatric illness. Biological factors that integrate neurobiology and behavior could become important targets to improve treatment outcome. This study highlights the importance of weight normalization and taste perception the normalization of brain function, and food type or taste\u2010specific interventions could help in the recovery process. Furthermore, the study suggests that food\u2010related and nonfood\u2010related reward processing adapts to illness state in AN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23814","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T13:19:16Z","timestamp":1663852756000},"page":"1799-1810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brain reward response in adolescents and young adults with anorexia nervosa is moderated by changes in body weight and sweetness perception"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-3441","authenticated-orcid":false,"given":"Guido K. 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