{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:27:23Z","timestamp":1784309243675,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005389","name":"American Psychological Association of Graduate Students","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005389","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005197","name":"Hilda and Preston Davis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005290","name":"Psi Chi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Elevated glucose variability may be one mechanism that increases risk for significant psychological and physiological health conditions among individuals with binge\u2010spectrum eating disorders (B\u2010EDs), given the impact of eating disorder (ED) behaviors on blood glucose levels. This study aimed to characterize glucose variability among individuals with B\u2010EDs compared with age\u2010matched, sex\u2010matched, and body mass index\u2010matched controls, and investigate the association between frequency of ED behaviors and glucose variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were 52 individuals with B\u2010EDs and 22 controls who wore continuous glucose monitors to measure blood glucose levels and completed ecological momentary assessment surveys to measure ED behaviors for 1 week. Independent samples <jats:italic>t<\/jats:italic>\u2010tests compared individuals with B\u2010EDs and controls and multiple linear regression models examined the association between ED behaviors and glucose variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with B\u2010EDs demonstrated numerically higher glucose variability than controls (<jats:italic>t<\/jats:italic>\u00a0=\u00a01.42, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.08, <jats:italic>d<\/jats:italic>\u00a0=\u00a00.43), although this difference was not statistically significant. When controlling for covariates, frequency of ED behaviors was significantly, positively associated with glucose variability (<jats:italic>t<\/jats:italic>\u00a0=\u00a03.17, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) with medium effect size (<jats:italic>f<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u00a0=\u00a00.25). Post hoc analyses indicated that binge eating frequency was significantly associated with glucose variability, while episodes of 5+ hours without eating were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Glucose variability among individuals with B\u2010EDs appears to be positively associated with engagement in ED behaviors, particularly binge eating. Glucose variability may be an important mechanism by which adverse health outcomes occur at elevated rates in B\u2010EDs and warrants future study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance<\/jats:title><jats:p>This study suggests that some individuals with binge ED and bulimia nervosa may experience elevated glucose variability, a physiological symptom that is linked to a number of adverse health consequences. The degree of elevation in glucose variability is positive associated with frequency of eating disorder behaviors, especially binge eating.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23838","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T09:05:25Z","timestamp":1666947925000},"page":"1788-1798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Glucose variability: A physiological correlate of eating disorder behaviors among individuals with binge\u2010spectrum eating disorders"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-1207","authenticated-orcid":false,"given":"Emily K.","family":"Presseller","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences Drexel University  Philadelphia Pennsylvania USA"},{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Gabrielle G.","family":"Patarinski","sequence":"additional","affiliation":[{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Drexel University  Philadelphia Pennsylvania USA"},{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Medicine Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paakhi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-588X","authenticated-orcid":false,"given":"Stephanie M.","family":"Manasse","sequence":"additional","affiliation":[{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne S.","family":"Juarascio","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences Drexel University  Philadelphia Pennsylvania USA"},{"name":"Center for Weight, Eating, and Lifestyle Sciences Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procs.2016.09.452"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.5.1023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4901-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1581"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086284"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111274"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(02)00829-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.235"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2010.0247"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.040"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.06.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.2260150404"},{"key":"e_1_2_9_14_1","unstructured":"Juarascio A. 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