{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:19:17Z","timestamp":1770495557795,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["288696"],"award-info":[{"award-number":["288696"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118278"],"award-info":[{"award-number":["R01MH118278"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH119084"],"award-info":[{"award-number":["R01MH119084"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH124871"],"award-info":[{"award-number":["R01MH124871"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH120170"],"award-info":[{"award-number":["R01MH120170"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["538\u20102013\u20108864"],"award-info":[{"award-number":["538\u20102013\u20108864"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R276\u20102018\u20104581"],"award-info":[{"award-number":["R276\u20102018\u20104581"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the association between <jats:italic>continued<\/jats:italic> antidepressant use in pregnancy and postpartum psychiatric visits for eating (ED) or mood\/anxiety disorders in women with preexisting ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using Danish health registry data (1998\u20132015), we identified 3529 pregnancies in women with ED prepregnancy: (i) 564 with <jats:italic>continued<\/jats:italic> antidepressant use before and during pregnancy; (ii) 778 with <jats:italic>discontinued<\/jats:italic> antidepressants before pregnancy; (iii) 2137 <jats:italic>unexposed<\/jats:italic>. Outpatient and inpatient postpartum visits for an ED or a mood\/anxiety disorder constituted the outcome measures. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) using Cox regression with inverse probability of treatment weighting, and performed stratified analyses by antidepressant prescription filling in the first 3 months postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The weighted cumulative incidence for an ED visit at end of follow\u2010up was 4.5% (<jats:italic>continued<\/jats:italic>) and 4.8% (<jats:italic>discontinued<\/jats:italic>). We found no association between <jats:italic>continued<\/jats:italic> antidepressant and postpartum ED visit, relative to <jats:italic>discontinued<\/jats:italic> (HR: 0.89, 95% CI: 0.52\u20131.52). The HR for postpartum mood\/anxiety disorder visit was 1.27 (95% CI: 0.68\u20132.36) with <jats:italic>continued<\/jats:italic> antidepressants versus <jats:italic>discontinued<\/jats:italic> but decreased if more than two antidepressant prescriptions were refilled. <jats:italic>Continued<\/jats:italic> antidepressant use was associated with a 57% reduced likelihood of a postpartum ED visit versus <jats:italic>discontinued<\/jats:italic> use in pregnancies with antidepressant prescription refills in the early postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among women with preexisting ED, there was no association between <jats:italic>continued<\/jats:italic> antidepressant use during pregnancy and the likelihood of postpartum psychiatric visits, relative to <jats:italic>discontinued<\/jats:italic> antidepressants before pregnancy. <jats:italic>Continuation<\/jats:italic> of treatment into the early postpartum is associated with reduced likelihood of postpartum ED visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance<\/jats:title><jats:p>Based on data from the Danish registries, we identified 3529 pregnancies among women with preexisting eating disorders before pregnancy. Women with continued antidepressant treatment both before and during pregnancy did not have a lower probability of having postpartum psychiatric visits for an eating disorder or for mood\/anxiety disorders (often coexisting with eating disorders), relative to those who discontinued antidepressants before pregnancy. Further continuation of antidepressant treatment into the early postpartum is associated with improved maternal postpartum outcomes. However, residual confounding by disease severity limits confidence in this conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23877","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:54:16Z","timestamp":1671191656000},"page":"582-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psychiatric visits during the postpartum year in women with eating disorders who continue or discontinue antidepressant treatment in pregnancy"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-5322","authenticated-orcid":false,"given":"Nhung T. H.","family":"Trinh","sequence":"first","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-7066","authenticated-orcid":false,"given":"Birgitte Dige","family":"Semark","sequence":"additional","affiliation":[{"name":"NCRR\u2014The National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"},{"name":"CIRRAU\u2014Centre for Integrated Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-7147","authenticated-orcid":false,"given":"Trine","family":"Munk\u2010Olsen","sequence":"additional","affiliation":[{"name":"NCRR\u2014The National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-1536","authenticated-orcid":false,"given":"Xiaoqin","family":"Liu","sequence":"additional","affiliation":[{"name":"NCRR\u2014The National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-1960","authenticated-orcid":false,"given":"\u00d8yvind","family":"R\u00f8","sequence":"additional","affiliation":[{"name":"Regional Department for Eating Disorders, Division of Mental Health and Addiction Oslo University Hospital  Oslo Norway"},{"name":"Division of Mental Health and Addiction, Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-3264","authenticated-orcid":false,"given":"Cynthia M.","family":"Bulik","sequence":"additional","affiliation":[{"name":"UNC Center of Excellence for Eating Disorders, Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Nutrition University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-5941","authenticated-orcid":false,"given":"Leila","family":"Torgersen","sequence":"additional","affiliation":[{"name":"Department of Child Health and Development Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-3183","authenticated-orcid":false,"given":"Angela","family":"Lupattelli","sequence":"additional","affiliation":[{"name":"PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-5379","authenticated-orcid":false,"given":"Liselotte Vogdrup","family":"Petersen","sequence":"additional","affiliation":[{"name":"NCRR\u2014The National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"263","article-title":"The Danish National Hospital Register. A valuable source of data for modern health sciences","volume":"46","author":"Andersen T. F.","year":"1999","journal-title":"Danish Medical Bulletin"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003391"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-018-0809-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2675"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19r13134"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028956"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000724"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13143"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000358"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10393"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494815575193"},{"key":"e_1_2_10_15_1","unstructured":"Greifer N.(2021).Covariate Balance Tables and Plots: A Guide to the cobalt Package.https:\/\/cran.r-project.org\/web\/packages\/cobalt\/vignettes\/cobalt.html"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.03.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-013-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c1ea43"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181875e61"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10222"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/j.1600-0412.1999.780406.x"},{"issue":"11","key":"e_1_2_10_22_1","first-page":"464","article-title":"An open trial of fluoxetine in patients with anorexia nervosa","volume":"52","author":"Kaye W. H.","year":"1991","journal-title":"The Journal of Clinical Psychiatry"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22088"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.067"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003895"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22352"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133045"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.12.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.11.003"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03467.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.09.034"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22104"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002018.pub2"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2202\/1557-4679.1106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200109000-00006"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06090blu"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007390"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-016-0619-3"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30136-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00011"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1750598"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-016-0709-2"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09162"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.02.011"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24741-0_15"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61277-0"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3798"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.04.101"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11010148"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.22.2605"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39393.689595.BE"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000241"},{"key":"e_1_2_10_57_1","unstructured":"WHOInternational statistical classification of diseases and related health problems 10th revision.http:\/\/apps.who.int\/classifications\/icd10\/browse\/2015\/en"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4336"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/1.4.423"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3182306847"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.23877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.23877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T11:08:01Z","timestamp":1692356881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.23877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/eat.23877"],"URL":"https:\/\/doi.org\/10.1002\/eat.23877","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"2022-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}