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After two authors screened articles and extracted data, 30 articles met inclusion criteria. Data were coded, and a risk bias was conducted for each study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The majority of studies focused on muscle size\/lean mass (60%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200918) and energy expenditure (33%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20099), with few studies (17%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20095) investigating muscle function or possible mechanisms underlying muscle size (20%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u20096). Studies supported that individuals with AN have smaller muscle size and reduced energy expenditure relative to controls. In some studies (33%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200910) recovery from AN was not sufficient to restore muscle mass or function. Mechanisms underlying short and long\u2010term musculoskeletal alterations have not been thoroughly explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Muscle mass and strength loss may be an unexplored component of physiological deterioration during and after AN. More research is necessary to understand intramuscular alterations during AN and interventions to facilitate muscle mass and functional gain following weight restoration in AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Public Significance<\/jats:title>\n                    <jats:p>Muscle health is important for optimal health and is reduced in individuals with AN. However, we do not understand how muscle is altered at the cellular level throughout the course of AN. Here we review what is currently known regarding muscle health during AN and with weight restoration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.23878","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T22:09:55Z","timestamp":1671401395000},"page":"483-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Anorexia nervosa and muscle health: A systematic review of our current understanding and future recommendations for study"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-1021","authenticated-orcid":false,"given":"Megan E.","family":"Rosa\u2010Caldwell","sequence":"first","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-0930","authenticated-orcid":false,"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-3312","authenticated-orcid":false,"given":"Seward B.","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-6519","authenticated-orcid":false,"given":"Lauren","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1829OC"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.10.1015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.10.2413"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00241.2006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-018-0525-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020247"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20619"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3685-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.078816"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.10.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2839"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.28608A"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/h11-132"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12070868"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.5.865"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.34908"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx061"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26958"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00536.2021"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.1.11"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2257OC"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1249\/jes.0000000000000173"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.07.017"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1100356"},{"key":"e_1_2_10_28_1","article-title":"Standard quality assessment criteria for evaluating primary research papers from a variety of fields","author":"Kmet L. 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