{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:57:04Z","timestamp":1780581424949,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 110\u20102314\u2010B\u2010038\u2010070"],"award-info":[{"award-number":["MOST 110\u20102314\u2010B\u2010038\u2010070"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate natural\u2010 and unnatural\u2010cause mortality at different follow\u2010up time points in Taiwanese patients with anorexia nervosa (AN) and bulimia nervosa (BN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this longitudinal cohort study, 330,393 patients, including 2143 patients with AN, 13,590 with BN, and 20 times as many respective non\u2010AN and non\u2010BN patients, were followed up for 16\u2009years. We performed conditional Cox regression survival analysis to examine the risk of mortality in the AN and BN groups relative to the comparison group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1242 patients died, including 101 and 343 patients with AN and BN, respectively. Mortality rates for AN and BN were 5.42 and 2.90 deaths per 1000 person\u2010years, respectively. Compared with the non\u2010AN group, the AN group had a significantly higher risk of both natural\u2010 and unnatural\u2010cause mortality, and the BN group had a significantly higher risk of unnatural\u2010cause mortality. Suicide was the most common cause of death, and suicide risk was significantly higher in both the AN and BN groups. All\u2010cause mortality risk was the highest at the beginning of follow\u2010up and markedly declined in the AN group. In the BN group, all\u2010cause mortality risk was lower but stable at follow\u2010up. The risk of unnatural\u2010cause mortality remained high throughout the follow\u2010up period for both the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early detection and treatment for associated physical problems in patients with AN are crucial. Regular monitoring for unnatural\u2010cause mortality events (mainly suicide) in AN and BN over time is also crucial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance<\/jats:title><jats:p>AN had a significantly higher risk of both natural\u2010 and unnatural\u2010cause mortality and BN had a significantly higher risk of death from unnatural causes. All\u2010cause mortality risk was highest at the beginning of follow\u2010up in AN, but unnatural\u2010cause mortality risk remained high throughout the follow\u2010up period for both groups. Our findings imply that early detection and treatment in AN and regular monitoring for unnatural\u2010cause mortality events in AN and BN are crucial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.23934","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T10:11:02Z","timestamp":1678788662000},"page":"1135-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mortality in anorexia nervosa and bulimia nervosa: A population\u2010based cohort study in Taiwan, 2002\u20132017"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-102X","authenticated-orcid":false,"given":"Mei\u2010Chih Meg","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry, Shuang Ho Hospital Taipei Medical University  New Taipei City Taiwan"},{"name":"Department of Psychiatry National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Nien","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Health and Welfare Policy, College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Graduate Institute of Data Science, College of Management Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Ying","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Psychiatry National Taiwan University Hospital Yunlin Branch  Yunlin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Data Science, College of Management Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002768"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20904"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.1332"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg296"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020247"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2019.153"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1990-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-2433-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-108x(199904)25:3<243::aid-eat1>3.0.co;2-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-020-00960-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22501"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7954-10-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12070868"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13261"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.1.11"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-018-0937-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-019-01667-0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2178"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.06.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2020.197"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000342"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2014.07.017"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.29805\/JHM.200606.0001"},{"issue":"6","key":"e_1_2_10_28_1","first-page":"365","article-title":"Comparison of official coders versus physician panel in assignment of underlying cause of death","volume":"100","author":"Lu T. 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