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ABA vulnerability was compared within and across two groups of animals: those injected intraperitoneally with 30\u2009mg\/kg ketamine for three consecutive days (30mgKetx3) during the second ABA in late adolescence (ABA2) or with vehicle only (Vx3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vx3 females and males exhibited individual differences in wheel running and weight retention during first ABA in mid\u2010adolescence (ABA1), ABA2, and third ABA in adulthood (ABA3). Their wheel running correlated with anxiety\u2010like behavior. During ABA1 and ABA3, weight gain of Vx3 females (but not males) after food consumption correlated negatively with food\u2010anticipatory activity (FAA) preceding the feeding hours, indicating that females with higher levels of running restrict feeding more and persistently. This paradoxical relationship confirms earlier findings of ABA females without ketamine treatment, capturing the maladaptive behaviors exhibited by individuals diagnosed with anorexia nervosa. By contrast, 30mgKetx3 had an effect on both sexes of reducing hyperactivity during the feeding hours acutely and reducing anxiety\u2010like behavior's contribution to running. For females, only, 30mgKetx3 acutely improved the extent of compensatory food consumption relative to FAA and improved weight retention during ABA3, 12\u2009days post ketamine in adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Sub\u2010anesthetic ketamine evokes behavior\u2010specific ameliorative effects for adult mice re\u2010experiencing ABA, supporting the notion that multiple doses of ketamine may be helpful in reducing relapse among adults with anorexia nervosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance Statement<\/jats:title><jats:p>This study examined whether ketamine reduces anorexia\u2010like behaviors in adult mice. Three daily\u00a0sub\u2010anesthetic ketamine injections suppress wheel running during and leading up to the hours of food availability and enable animals to compensate better for weight loss associated with excessive exercise by eating more. These findings suggest that ketamine may help adult females diagnosed with anorexia nervosa but also point to sex\u2010 and age\u2010related differences in the action of ketamine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24036","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:44:33Z","timestamp":1690983873000},"page":"1447-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Three daily intraperitoneal injections of sub\u2010anesthetic ketamine ameliorate activity\u2010based anorexia vulnerability of adult female mice"],"prefix":"10.1002","volume":"57","author":[{"given":"Sebastian","family":"Goodwin\u2010Groen","sequence":"first","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Dong","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4010-9425","authenticated-orcid":false,"given":"Chiye","family":"Aoki","sequence":"additional","affiliation":[{"name":"Center for Neural Science New York University  New York New York USA"},{"name":"Neuroscience Institute NYU Langone Medical Center, New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Activity\u2010based anorexia, an animal model of anorexia nervosa for investigating brain plasticity underlying the gain of resilience","author":"Aoki C.","year":"2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.01.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.990354"},{"key":"e_1_2_9_5_1","volume-title":"Diagnostic and statistical manual of mental disorders DSM\u20105","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242897"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554-07.2007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2273-21.2022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.10.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.4009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000453"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199401)15:1<21::AID-EAT2260150104>3.0.CO;2-K"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20164"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.2996"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3304"},{"issue":"6","key":"e_1_2_9_17_1","first-page":"1","article-title":"Titrated serial ketamine infusions stop outpatient suicidality and avert ER visits and hospitalizations","volume":"2","author":"Calabrese L.","year":"2019","journal-title":"International Journal of Methods in Psychiatric Research"},{"key":"e_1_2_9_18_1","volume-title":"Sequenced ketogenic diet and ketamine infusions for chronic anorexia:A pilot study. 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