{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:39:25Z","timestamp":1792028365565,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An extensive number of predictors has been examined across the literature to improve knowledge of relapse in anorexia nervosa (AN). These studies provide various recovery and relapse definitions, follow\u2010up durations and relapse rates. The current study summarizes these values and predictors of relapse in AN in a review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was executed according to PRISMA guidelines. Different databases were searched and studies in which participants did not receive an official clinical diagnosis were excluded. A quality analysis was performed using the National Institute of Health's Study Quality Assessment Tool. Random\u2010effects meta\u2010analyses were conducted to summarize data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Definitions of relapse and recovery were diverse. During an average follow\u2010up period of 31\u2009months an average relapse rate of 37% was found. Predictive variables from 28 studies were grouped in six categories: age and sex, symptoms and behaviors, AN subtype and duration, weight or weight change, comorbidity, and personality. The studies were characterized by non\u2010significant and contradictory results. Meta\u2010analyses were performed for the predictors age, AN duration, pre\u2010treatment BMI, post\u2010treatment BMI and depression. These yielded significant effects for post\u2010treatment BMI and depression: higher pre\u2010treatment depression (SMD\u2009=\u2009.40 CI [.21\u2013.59] and lower post\u2010treatment BMI (SMD\u2009=\u2009\u2212.35 CI [\u2212.63 to \u2212.07]) increased relapse chances in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results emphasized a lack of sufficiently powered studies, consistent results, and robust findings. Solely post\u2010treatment BMI and pre\u2010treatment depression predicted relapse. Future research should use uniform definitions, larger samples and better designs, to improve our understanding of relapse in AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public significance<\/jats:title><jats:p>Knowledge about predictors is important to understand high relapse rates. Our study performed a review and meta\u2010analysis of relapse predictors in AN. Related to the heterogeneity in studies examining predictors, an overview of relapse and recovery definitions, follow\u2010up durations and relapse rates for AN was provided. Significant effects were found for post\u2010treatment BMI and pre\u2010treatment depression. More studies with uniform definitions are needed to improve clinical implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24059","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T09:21:18Z","timestamp":1697707278000},"page":"3-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["An overview and investigation of relapse predictors in anorexia nervosa: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-142X","authenticated-orcid":false,"given":"Eline S. 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