{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:10:26Z","timestamp":1791497426874,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the plasma lipidome of patients with anorexia nervosa (AN) before and after weight restoration treatment and report associations with AN subtypes and oral contraceptive pill (OCP) usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative shotgun lipidomics analysis was used to study plasma lipids of 50 female patients with AN before and after weight restoration treatment and 50 healthy female controls (HC). The AN group was assessed with blood samples and questionnaires before and after weight restoration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total we quantified 260 lipid species representing 26 lipid classes of which 13 lipid class concentrations were elevated in patients with AN at admission compared with HC. Lipid classes remained elevated after weight restoration treatment of 84\u2009days (median; interquartile range 28), and only the concentration of the ceramide lipid class increased between pre\u2010 and post\u2010treatment (<jats:italic>p<\/jats:italic>\u2009=\u2009.03), whereas lysophosphatidylcholine (LPC, <jats:italic>p<\/jats:italic>\u2009=\u2009.02), ether\u2010linked Phosphatidylcholine (LPCO, <jats:italic>p<\/jats:italic>\u2009=\u2009.02), and lysophosphatidylethanolamine (LPE, <jats:italic>p<\/jats:italic>\u2009=\u2009.009) decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In AN, 13 out of 26 lipid class concentrations were elevated at admission and remained elevated post\u2010treatment. Ceramides increased further between pre\u2010 and post\u2010weight restoration treatment, which could be related to the rapid weight gain during re\u2010nutrition. Further research is needed to elucidate the effects of weight restoration treatment on short\u2010 and long\u2010term lipid profiles in individuals with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance Statement<\/jats:title><jats:p>Lipidomics research can increase the understanding of AN, a complex and potentially life\u2010threatening eating disorder. By analyzing lipids, or fats, in the body, we can identify biological markers that may inform diagnosis and develop more effective treatments. This research can also shed light on the underlying mechanisms of the disorder, leading to a better understanding of the processes involved in eating behavior.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24063","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T04:53:49Z","timestamp":1694840029000},"page":"2260-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated lipid class concentrations in females with anorexia nervosa before and after intensive weight restoration treatment\u2014A lipidomics study"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-5165","authenticated-orcid":false,"given":"Alia Arif","family":"Hussain","sequence":"first","affiliation":[{"name":"Eating Disorder Research Unit, Mental Health Center, Ballerup Copenhagen University Hospital\u2013Mental Health Services CPH  Copenhagen Denmark"},{"name":"Department of 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Lykke","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Unit of Medical Psychology, Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"Center for Healthy Aging University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Bulik","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institute  Stockholm Sweden"},{"name":"Department of Nutrition University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-5544","authenticated-orcid":false,"given":"Ren\u00e9 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