{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:33:53Z","timestamp":1791045233727,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000124","name":"NIH ORWH","doi-asserted-by":"publisher","award":["8K12AR084233\u201003"],"award-info":[{"award-number":["8K12AR084233\u201003"]}],"id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32MH096679"],"award-info":[{"award-number":["T32MH096679"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The explore\/exploit trade\u2010off is a decision\u2010making process that is conserved across species and balances exploring unfamiliar choices of unknown value with choosing familiar options of known value to maximize reward. This framework is rooted in behavioral ecology and has traditionally been used to study maladaptive versus adaptive non\u2010human animal foraging behavior. Researchers have begun to recognize the potential utility of understanding human decision\u2010making and psychopathology through the explore\/exploit trade\u2010off. In this article, we propose that explore\/exploit trade\u2010off holds promise for advancing our mechanistic understanding of decision\u2010making processes that confer vulnerability for and maintain eating pathology due to its neurodevelopmental bases, conservation across species, and ability to be mathematically modeled. We present a model for how suboptimal explore\/exploit decision\u2010making can promote disordered eating and present recommendations for future research applying this framework to eating pathology. Taken together, the explore\/exploit trade\u2010off provides a translational framework for expanding etiologic and maintenance models of eating pathology, given developmental changes in explore\/exploit decision\u2010making that coincide in time with the emergence of eating pathology and evidence of biased explore\/exploit decision\u2010making in psychopathology. Additionally, understanding explore\/exploit decision\u2010making in eating disorders may improve knowledge of their underlying pathophysiology, informing targeted clinical interventions such as neuromodulation and pharmacotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance Statement<\/jats:title><jats:p>The explore\/exploit trade\u2010off is a cross\u2010species decision\u2010making process whereby organisms choose between a known option with a known reward or sampling unfamiliar options. We hypothesize that imbalanced explore\/exploit decision\u2010making can promote disordered eating and present preliminary data. We propose that explore\/exploit trade\u2010off has significant potential to advance understanding of the neurocognitive and neurodevelopmental mechanisms of eating pathology, which could ultimately guide revisions of etiologic models and inform novel interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24173","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T13:28:25Z","timestamp":1708608505000},"page":"1102-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The explore\/exploit trade\u2010off: An ecologically valid and translational framework that can advance mechanistic understanding of eating disorders"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-3591","authenticated-orcid":false,"given":"Kelsey E.","family":"Hagan","sequence":"first","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Institute for Women's Health Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivieosa","family":"Aimufua","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York State Psychiatric Institute, Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-1731","authenticated-orcid":false,"given":"Ann F.","family":"Haynos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Department of Psychology Virginia Commonwealth University  Richmond Virginia USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-5859","authenticated-orcid":false,"given":"B. 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