{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:38:26Z","timestamp":1791639506784,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) and atypical AN are conceptualized as distinct illnesses, despite similar characteristics and sequelae. Whereas DSM\u20105 differentiates youth with AN and atypical AN by the presence of clinical \u2018underweight\u2019 (i.e., 5th BMI percentile for age\u2010and\u2010sex (BMI%)), we hypothesized that using this weight cut\u2010off to discern diagnoses creates a skewed distribution for premorbid weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Participants included hospitalized youth with AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009165, 43.1%) and atypical AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009218, 56.9%). Frequency analyses and chi\u2010square tests assessed the distribution of premorbid BMI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores (BMIz) for diagnosis. Non\u2010parametric Spearman correlations and Stepwise Linear regressions examined relationships between premorbid BMIz, admission BMIz, and weight loss in kg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Premorbid BMIz distributions differed significantly for diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), with an underrepresentation of \u2018overweight\/obesity\u2019 (i.e., BMI%\u2009\u2265\u200985th) in AN. Despite commensurate weight loss in AN and atypical AN, patients with premorbid \u2018overweight\/obesity\u2019 were 8.31 times more likely to have atypical AN than patients with premorbid BMI%\u2009&lt;\u200985th. Premorbid BMIz explained 57% and 39% of the variance in admission BMIz and weight loss, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Findings support a homogenous model of AN and atypical AN, with weight loss predicted by premorbid BMI in both illnesses. Accordingly, premorbid BMI and weight loss (versus presenting BMI) may better denote the presence of an AN\u2010like phenotype across the weight spectrum. Findings also suggest that differentiating diagnoses with BMI%\u2009&lt;\u20095th requires that youth with higher BMIs lose disproportionately more weight for an AN diagnosis. This is problematic given unique treatment barriers experienced in atypical AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Public significance<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) and atypical AN are considered distinct conditions in youth, with differential diagnosis hinging upon a presenting weight status of \u2018underweight\u2019 (i.e., BMI percentile for age\u2010and\u2010sex (BMI%)\u2009&lt;\u20095th). In our study, youth with premorbid \u2018overweight\/obesity\u2019 (BMI%\u2009\u2265\u200985th) disproportionately remained above this threshold, despite similar weight loss. Coupled with prior evidence for commensurate characteristics and sequelae in both diagnoses, we propose that DSM\u20105 differentiation of AN and atypical AN inadvertently reinforces weight stigma and may contribute to treatment disparities in atypical AN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24188","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T23:19:39Z","timestamp":1709939979000},"page":"983-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Differentiating anorexia nervosa and atypical anorexia nervosa with absolute weight cut\u2010offs results in a skewed distribution for premorbid weight among youth"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-2589","authenticated-orcid":false,"given":"Abigail","family":"Matthews","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-6913","authenticated-orcid":false,"given":"Jessica","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Adolescent and Transition Medicine Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Division of Adolescent and Young Adult Medicine Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Jhe","sequence":"additional","affiliation":[{"name":"Division of Adolescent and Young Adult Medicine Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-2802","authenticated-orcid":false,"given":"Triinu","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"},{"name":"Center for Translational Neuro\u2010 and Behavioral Sciences, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-1862","authenticated-orcid":false,"given":"Leslie","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-6073","authenticated-orcid":false,"given":"Johannes","family":"Hebebrand","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"},{"name":"Center for Translational Neuro\u2010 and Behavioral Sciences, University Hospital Essen University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22598"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-023-00779-y"},{"key":"e_1_2_9_7_1","unstructured":"Center for Disease Control and Prevention. 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