{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:30:20Z","timestamp":1788982220038,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to compare the effectiveness of an intensive treatment based on enhanced cognitive\u2010behavioral therapy (CBT\u2010E) in patients aged between 12 and 18\u2009years with anorexia nervosa with a duration of illness &lt;3 versus \u22653\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and fifty\u2010nine consecutively treated patients (<jats:italic>n<\/jats:italic>\u2009=\u2009122 with illness duration &lt;3\u2009years and <jats:italic>n<\/jats:italic>\u2009=\u200937\u2009\u2265\u20093\u2009years) were enrolled in a 20\u2010week intensive CBT\u2010E program. All patients underwent assessment at admission, end of treatment (EOT), and 20\u2010week follow\u2010up. The following measures were used: body mass index (BMI)\u2010for\u2010age percentile and percentage of expected body weight (EBW), Eating Disorder Examination Questionnaire, Brief Symptom Inventory, and Clinical Impairment Assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 81% of eligible patients began the program, with over 80% successfully completing it. Patients with a longer or shorter duration of illness did not show significantly different treatment outcomes. In detail, BMI\u2010for\u2010age percentile and percentage of EBW outcomes were significantly improved from baseline to EOT, remaining stable until 20\u2010week follow\u2010up in both groups. Similarly, in both groups, scores for eating disorder psychopathology, general psychopathology, and clinical impairment decreased significantly at EOT and remained stable from EOT to follow\u2010up. Furthermore, a substantial percentage of adolescents in both groups achieved a good BMI outcome at EOT and 20\u2010week follow\u2010up, with approximately 60% maintaining a full response at the latter time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggest that intensive CBT\u2010E appears to be an effective treatment for severely ill adolescent patients with anorexia nervosa, regardless of whether the duration of illness is shorter or longer than 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Public Significance<\/jats:title><jats:p>Existing treatment outcome studies in adolescents, whether randomized controlled trials or longitudinal investigations, typically involve patients with less than 3\u2009years of illness, while data on the treatment outcomes for adolescents with anorexia nervosa with an illness duration of 3\u2009years or over is very limited. Our findings suggest that adolescents with anorexia nervosa, irrespective of the duration of their illness, can derive similar benefits from intensively CBT\u2010E.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24196","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:21:44Z","timestamp":1710415304000},"page":"1566-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Illness duration and treatment outcome of intensive cognitive\u2010behavioral therapy in adolescents with anorexia nervosa"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-1877","authenticated-orcid":false,"given":"Simona","family":"Calugi","sequence":"first","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-3721","authenticated-orcid":false,"given":"Anna","family":"Dalle Grave","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Chimini","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalle Grave","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2009.11.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.06.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-015-0057-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-016-0276-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-018-0477-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-7967(00)00033-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39238.399444.55"},{"key":"e_1_2_9_11_1","volume-title":"Intensive cognitive behavior therapy for eating disorders","author":"Dalle Grave R.","year":"2012"},{"key":"e_1_2_9_12_1","volume-title":"Cognitive behavior therapy for adolescents with eating disorders","author":"Dalle Grave R.","year":"2020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2012.09.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23337"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23765"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23122"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23867"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1993.tb01045.x"},{"key":"e_1_2_9_20_1","volume-title":"The brief symptom inventory (BSI): Administration, scoring & procedures manual\u2010II","author":"Derogatis L. 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