{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:02:56Z","timestamp":1791298976554,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adults with binge\u2010eating disorder (BED), compared with those without BED, demonstrate higher blood\u2010oxygen\u2013level\u2010dependent (BOLD) response to food cues in reward\u2010related regions of the brain. It is not known whether cognitive behavioral therapy (CBT) can reverse this reward system hyperactivation. This randomized controlled trial (RCT) assessed changes in BOLD response to binge\u2010eating cues following CBT versus wait\u2010list control (WLC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Females with BED (<jats:italic>N<\/jats:italic>\u2009=\u200940) were randomized to CBT or WLC. Participants completed assessments at baseline and 16\u2009weeks including measures of eating and appetite and functional magnetic resonance imaging (fMRI) to measure BOLD response while listening to personalized scripts of binge\u2010eating and neutral\u2010relaxing cues. Data were analyzed using general linear models with mixed effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall retention rate was 87.5%. CBT achieved significantly greater reductions in binge\u2010eating episodes than WLC (mean\u2009\u00b1\u2009standard error decline of 14.6\u2009\u00b1\u20092.7 vs. 5.7\u2009\u00b1\u20092.8 episodes in the past 28\u2009days, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). CBT and WLC did not differ significantly in changes in neural responses to binge\u2010eating stimuli during the fMRI sessions. Compared with WLC, CBT had significantly greater improvements in reward\u2010based eating drive, disinhibition, and hunger as assessed by questionnaires (<jats:italic>p<\/jats:italic>s\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>CBT was effective in reducing binge eating, but, contrary to our hypothesis, CBT did not improve BOLD response to auditory binge\u2010eating stimuli in reward regions of the brain. Further studies are needed to assess mechanisms underlying improvements with CBT for BED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT03604172<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24244","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T10:36:14Z","timestamp":1719916574000},"page":"1911-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge\u2010Eating Disorder"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-8973","authenticated-orcid":false,"given":"Ariana M.","family":"Chao","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Nursing  Baltimore Maryland USA"},{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania School of Nursing  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"},{"name":"National Institute of Nursing Research  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-7714","authenticated-orcid":false,"given":"Khushbu","family":"Agarwal","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"},{"name":"National Institute of Nursing Research  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania School of Nursing  Philadelphia Pennsylvania USA"},{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-3444","authenticated-orcid":false,"given":"Carlos M.","family":"Grilo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Psychology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-1996","authenticated-orcid":false,"given":"Ruben C.","family":"Gur","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-9622","authenticated-orcid":false,"given":"Paule","family":"Joseph","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism  Bethesda Maryland USA"},{"name":"National Institute of Nursing Research  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-8203","authenticated-orcid":false,"given":"Russell T.","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Center for Biomedical Image Computing and Analytics University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese S.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences University of Pennsylvania School of Nursing  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-4609","authenticated-orcid":false,"given":"Thomas A.","family":"Wadden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Handling Missing Data by Maximum Likelihood","author":"Allison P. 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