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Research on the etiology of this common comorbidity has not explored the potential for shared genetic risk. This study examined genetic and environmental influences on LOC eating and its shared influence with BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants were 499 monozygotic and 398 same\u2010sex dizygotic twins (age\u2009=\u200917.38\u2009years\u2009\u00b1\u20090.67, BMIz\u2009=\u20090.03\u2009\u00b1\u20091.03, 54% female) from the Colorado Center for Antisocial Drug Dependence Study. LOC eating was assessed dichotomously. Self\u2010reported height and weight were converted to BMIz. Univariate and bivariate twin models estimated genetic and environmental influences on LOC eating and BMIz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More girls (21%) than boys (9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) reported LOC eating. The phenotypic correlation with BMIz was 0.03 in girls and 0.18 in boys. Due to the nonsignificant phenotypic correlation in girls, bivariate twin models were fit in boys only. Across all models, the best\u2010fitting model included genetic and unique environmental effects. Genetic factors accounted for 0.51 (95% CI: 0.23, 0.73) of the variance of LOC eating in girls and 0.54 (0.18, 0.90) in boys. The genetic correlation between LOC eating and BMIz in boys was 0.45 (0.15, 0.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Findings indicate moderate heritability of LOC eating in adolescence, while emphasizing the role of unique environmental factors. In boys, LOC eating and BMIz share a proportion of their genetic influences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24245","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T10:29:28Z","timestamp":1719570568000},"page":"2128-2134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared Genetic Influences Between Loss\u2010of\u2010Control Eating and Body Mass Index in Adolescent Twins"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-9141","authenticated-orcid":false,"given":"Camden E.","family":"Matherne","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-7055","authenticated-orcid":false,"given":"Baiyu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyun","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience University of Colorado Boulder  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics, University of Colorado Boulder  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Stallings","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience University of Colorado Boulder  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics, University of Colorado Boulder  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin P.","family":"Corley","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Genetics, University of Colorado Boulder  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience University of Colorado Boulder  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics, University of Colorado Boulder  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-9457","authenticated-orcid":false,"given":"Melissa A.","family":"Munn\u2010Chernoff","sequence":"additional","affiliation":[{"name":"Department of Community, Family, and Addiction Sciences Texas Tech University  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294359"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23262"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11336\u2010010\u20109200\u20106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00280-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-019-0327-1"},{"key":"e_1_2_10_7_1","unstructured":"Centers for Disease Control and Prevention (CDC).2014.\u201cA SAS Program for the 2000 CDC Growth Charts (Ages 0 to<20\u2009Years) \u201dhttp:\/\/www.cdc.gov\/nccdphp\/dnpao\/growthcharts\/resources\/sas.htm."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.99"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001257"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00344-y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20484"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.12.1409"},{"key":"e_1_2_10_14_1","unstructured":"Kuczmarski R. 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