{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:14:06Z","timestamp":1787235246057,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0065175"],"award-info":[{"award-number":["NNF20OC0065175"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the overall pattern and timing of medical diagnoses up to 10\u2009years before an anorexia nervosa (AN) diagnosis and explores differences before and after AN diagnosis aiming to improve early detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this nationwide population\u2010based cohort study, we included all patients diagnosed with incident AN from 1987 to 2018 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913,345) and a 1:10 age\u2010 and sex\u2010matched general population comparison cohort, using Danish health registries. Using conditional logistic regression, we calculated odds ratios (ORs) of medical diagnoses up to 10\u2009years before AN diagnosis. Additionally, we calculated crude and adjusted hazard ratios (aHRs) for risk of medical diagnoses after AN diagnosis using Cox proportional hazards model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AN was associated with increased odds of any medical diagnosis up to 10\u2009years before AN diagnosis: OR 1.3 [95% CI 1.2\u20131.3] and the odds increased during the 12\u2009months preceding AN diagnosis: OR 1.6 [95% CI 1.5\u20131.7]. The medical diagnoses associated with the highest odds up to 10\u2009years prior AN were malnutrition: OR 5.0 [95% CI 4.0\u20136.3] anemia: OR 2.9 [95% CI 2.3\u20133.6], amenorrhea: OR 2.7 [95% CI 2.3\u20133.2], and irritable bowel syndrome: OR 2.1 [95% CI 1.9\u20132.4]. The pre\u2010diagnosis pattern mirrored the post\u2010diagnosis pattern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The similarity in diagnosis patterns before and after AN diagnosis suggests that many patients receive medical diagnoses for conditions potentially linked to AN\u2010related restricted eating, malnutrition and progressive weight loss even years prior to a formal AN diagnosis. Identifying these early conditions may enable earlier AN diagnosis and improve treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24340","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:29:28Z","timestamp":1736209768000},"page":"624-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patterns of Medical Diagnoses Before and After a Diagnosis of Anorexia Nervosa: A Danish Nationwide Cohort Study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-0776","authenticated-orcid":false,"given":"Mette","family":"S\u00f8eby","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-8347","authenticated-orcid":false,"given":"Loa","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Child and Adolescent Psychiatry Aarhus University Hospital, Psychiatry  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-9127","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Richelsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-6822","authenticated-orcid":false,"given":"Sigrid Bjerge","family":"Gribsholt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus, Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22598"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.74"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"Austin A. M.Flynn K.Richards et\u00a0al.2020.\u201cDuration of Untreated Eating Disorder and Relationship to Outcomes: A Systematic Review of the Literature.\u201dhttps:\/\/doi.org\/10.1002\/erv.2745.","DOI":"10.1002\/erv.2745"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.13139"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30386-9"},{"issue":"5","key":"e_1_2_12_7_1","first-page":"e77","article-title":"Gastrointestinal Manifestations of Eating Disorders","volume":"63","author":"Bern E. M.","year":"2023","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112501"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111077"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87a.19084"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"Fayssoil A. J. 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