{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:52:49Z","timestamp":1789487569924,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa, a restrictive eating disorder that is most commonly seen in females, is associated with alterations in gray matter (GM) and white matter (WM) structures. However, little is known about how restrained eating (RE) and the body mass index\u2010standard deviation score (BMI\u2010SDS) are related to brain morphology and whether sex differences exist in the general pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Participants were 9\u2010year\u2010old girls and boys (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092729) from the population\u2010based Generation R Study. BMI\u2010SDS was calculated by adjusting BMI for sex and age, using Dutch growth curves. RE is measured with the Dutch Eating Behavior Questionnaire. All children underwent structural magnetic resonance imaging, and brain volumes were calculated using FreeSurfer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BMI\u2010SDS in girls was positively associated with total intracranial volume and several regional brain volumes. In addition, BMI\u2010SDS showed an inverted U\u2010shaped association with total GM and WM. In girls, RE had a positive linear association with total intracranial, WM, and several regional brain volumes, corrected for BMI\u2010SDS. Additionally, there was an inverted U\u2010shaped association with the amygdala and insula volume. In boys, we found merely positive linear associations between BMI\u2010SDS and brain volumes, and no associations between RE and brain volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Associations between BMI and brain volumes exist in typically developing children, but there are significant sex differences in the magnitude and shape of the associations. RE is associated with some differences in brain volumes in girls only. Longitudinal studies are needed to assess these associations over a longer period of time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24445","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T05:53:13Z","timestamp":1745646793000},"page":"1440-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Restrained Eating Features and Brain Morphology: A Pediatric Population\u2010Based Study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-1101","authenticated-orcid":false,"given":"C. P. M.","family":"Steegers","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010Sophia Children's Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-3760","authenticated-orcid":false,"given":"M. E. J.","family":"Deen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010Sophia Children's Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-5803","authenticated-orcid":false,"given":"P. W.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"The Generation R Study Group Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Psychology, Education, and Child Studies Erasmus University Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-1896","authenticated-orcid":false,"given":"T.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry\/Psychology Erasmus MC\u2010Sophia Children's Hospital  Rotterdam the Netherlands"},{"name":"Department of Radiology and Nuclear Medicine Erasmus MC  Rotterdam the Netherlands"},{"name":"Section on Social and Developmental Cognitive Neuroscience National Institute of Mental Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-1749","authenticated-orcid":false,"given":"K. 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