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Given the importance of early weight gain during treatment for AN prognosis, WV could impact outcomes via effects on weight trends and related psychopathology. The current study examined whether WV and the slope of weight change predict eating disorder symptoms at the end of treatment (EOT) among adolescents with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Adolescents with AN (<jats:italic>N<\/jats:italic>\u2009=\u2009284) receiving residential treatment completed the Eating Disorder Examination Questionnaire (EDE\u2010Q) at admission and EOT. WV was calculated using the root\u2010mean\u2010squared\u2010error of daily weights over the first 14\u2009days of treatment. Linear regressions examined the effect of WV, slope of weight change over 14\u2009days, and their interaction on percent expected body weight (%EBW) and EDE\u2010Q scores at EOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WV positively predicted EDE\u2010Q Global Score (<jats:italic>p<\/jats:italic>\u2009=\u20090.033, <jats:italic>sr<\/jats:italic>\n<jats:sup>\n<jats:italic>2<\/jats:italic>\n<\/jats:sup>\u2009=\u20090.01), Shape Concern (<jats:italic>p<\/jats:italic>\u2009=\u20090.026, <jats:italic>sr<\/jats:italic>\n<jats:sup>\n<jats:italic>2<\/jats:italic>\n<\/jats:sup>\u2009=\u20090.01), and Weight Concern (<jats:italic>p<\/jats:italic>\u2009=\u20090.008, <jats:italic>sr<\/jats:italic>\n<jats:sup>\n<jats:italic>2<\/jats:italic>\n<\/jats:sup>\u2009=\u20090.02) at EOT. Neither WV nor the slope of weight change predicted %EBW at EOT (<jats:italic>p<\/jats:italic>s\u2009&gt;\u20090.05). The slope of weight change did not predict EDE\u2010Q, nor did it moderate the relation between WV and any outcomes (<jats:italic>p<\/jats:italic>s\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who experience greater weight fluctuations early in treatment may be more susceptible to elevated psychopathology at discharge. In light of few significant effects and small effect sizes, more research is needed to determine the putative role of early weight trends in adolescent AN outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/eat.24480","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:10:35Z","timestamp":1750147835000},"page":"1758-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-2924","authenticated-orcid":false,"given":"Simar","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-8547","authenticated-orcid":false,"given":"Sasha","family":"Gorrell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-0433","authenticated-orcid":false,"given":"Catherine R.","family":"Drury","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8697-9285","authenticated-orcid":false,"given":"Alan","family":"Duffy","sequence":"additional","affiliation":[{"name":"Eating Recovery Center and Pathlight Mood &amp; Anxiety Center  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-6428","authenticated-orcid":false,"given":"Philip S.","family":"Mehler","sequence":"additional","affiliation":[{"name":"Eating Recovery Center and Pathlight Mood &amp; Anxiety Center  Denver Colorado USA"},{"name":"Acute Center for Eating Disorders at Denver Health  Denver Colorado USA"},{"name":"University of Colorado School of Medicine  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8232-9098","authenticated-orcid":false,"given":"Kianna","family":"Zucker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-9496","authenticated-orcid":false,"given":"Daniel","family":"Le Grange","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"},{"name":"Department of Psychiatry and Behavioral Sciences The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-0747","authenticated-orcid":false,"given":"Erin E.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-7403","authenticated-orcid":false,"given":"Renee D.","family":"Rienecke","sequence":"additional","affiliation":[{"name":"Eating Recovery Center and Pathlight Mood &amp; 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