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We integrated behavioral and magnetic resonance spectroscopy (MRS) methods to characterize anxiety\u2010to\u2010eat and to identify its neurometabolic correlates in females with AN (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916) and in healthy weight females without a lifetime history of an eating disorder (healthy controls; HC;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916). Anxiety\u2010to\u2010eat was assessed via a computer\u2010based task in which participants rated their level of anxiety\u2010to\u2010eat on a visual analogue scale in response to images of a standard serving of higher (HED) and lower energy density (LED) foods. Levels of nine neurometabolites in the dorsal anterior cingulate cortex (dACC), a brain region putatively involved in modulating anxiety\u2010related responses, were assessed using edited MRS. The AN group reported greater anxiety\u2010to\u2010eat in response to HED and LED foods relative to the HC group. Both groups reported greater anxiety\u2010to\u2010eat in response to HED relative to LED foods. The neurometabolite myo\u2010inositol (myo\u2010I), a carbocyclic sugar and precursor molecule to phosphatidyl\u2010inositol species in second\u2010messenger systems shown to be dysregulated in AN (e.g., adrenergic, serotonergic, glutamatergic), was lower in the dACC in AN relative to HC. Additionally, in the AN group only, myo\u2010I levels negatively predicted anxiety\u2010to\u2010eat in response to HED but not LED foods independent of body mass index, duration of illness, and general anxiety. These findings raise the possibility that lower myo\u2010I in the dACC and its relationship with anxiety\u2010to\u2010eat responses\u00a0in AN reflect a distinct biological and behavioral phenotype of AN pathology. To understand the clinical implications of these findings, future studies should investigate the effect of treatment on myo\u2010I levels or directly manipulate myo\u2010I levels in the diet and assess resulting changes in anxiety\u2010to\u2010eat.\n                  <\/jats:p>","DOI":"10.1002\/eat.24549","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:55:03Z","timestamp":1760446503000},"page":"156-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myo\u2010Inositol Levels in the Dorsal Anterior Cingulate Cortex Are Associated With Anxiety\u2010to\u2010Eat in Anorexia Nervosa"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-7959","authenticated-orcid":false,"given":"Yulu","family":"Song","sequence":"first","affiliation":[{"name":"The Russel H. 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