{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:05:52Z","timestamp":1770685552292,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["259764"],"award-info":[{"award-number":["259764"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["538\u20102013\u20108864"],"award-info":[{"award-number":["538\u20102013\u20108864"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gestational high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), an established inflammatory biomarker, and subsequent risk of AN in daughters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This nested case\u2013control study with sibling\u2010comparison design used systematic sampling from a register\u2010based cohort including all eating disorder patients in Finland born 1991\u20132000 and diagnosed in specialized health care. Final sample included 150 full triads of females with severe AN (ICD\u201010 code F50.0), age\u2010 and sex\u2010matched population controls, and biological sister controls (total\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009450).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean gestational hs\u2010CRP values were 4.10\u2009mg\/L (SD 5.22), 4.83\u2009mg\/L (SD 4.88), and 5.53\u2009mg\/L (SD 10.36), for individuals with AN, population controls, and sister controls, respectively. Higher hs\u2010CRP was associated with decreased risk for AN when compared to sister controls (adjusted OR 0.68, 95% Cl 0.48\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Analyzing hs\u2010CRP in tertiles, maternal hs\u2010CRP in the highest tertile (\u2265\u20095.13\u2009mg\/L) versus lowest tertile (\u2264\u20091.94\u2009mg\/L) was associated with decreased risk for AN compared to sisters (adjusted OR 0.35, 95% Cl 0.15\u20130.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and to all controls combined (adjusted OR 0.52, 95% Cl 0.29\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We found no evidence that higher gestational CRP would increase the later risk of AN. On the contrary, lower maternal low\u2010grade inflammation early in pregnancy was associated with an increased risk of AN in daughters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24586","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:27:33Z","timestamp":1761308853000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Gestational Low\u2010Grade Inflammation and the Risk of Anorexia Nervosa in Daughters"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-554X","authenticated-orcid":false,"given":"Emma","family":"Saure","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Division of Adolescent Psychiatry Helsinki University Hospital  Helsinki 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2637-0818","authenticated-orcid":false,"given":"Elina","family":"Santti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Adolescent Psychiatry Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-1380","authenticated-orcid":false,"given":"Helj\u00e4\u2010Marja","family":"Surcel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Biobank Borealis of Northern Finland  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-117X","authenticated-orcid":false,"given":"Antti","family":"Latvala","sequence":"additional","affiliation":[{"name":"Institute of Criminology and Legal Policy University of Helsinki  Helsinki 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