{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:56:41Z","timestamp":1770677801015,"version":"3.49.0"},"reference-count":102,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a severe psychiatric disorder with structural brain alterations; however, the roles of cortical surface area (CSA) and cortical thickness (CTh) during adolescence remain unclear. Building on frequent reports of gray matter reductions in the cingulate cortex and precuneus, this study assesses CSA, CTh, and cortical volume in these regions, alongside exploratory whole\u2010brain analyses and their associations with psychological dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We included 26 adolescent females aged 12\u201319\u2009years with acute AN and 24 age\u2010matched healthy controls. Participants underwent high\u2010resolution structural MRI and completed psychological assessments: Eating Disorder Inventory\u20102 (EDI\u2010II), Beck Anxiety Inventory (BAI), Beck Depression Inventory\u2010II (BDI\u2010II), Perth Alexithymia Questionnaire (PAQ), and Body Perception Questionnaire. MRI data were processed using BIDScoin, fMRIPrep, and FreeSurfer. Analyses included permutation\u2010based non\u2010parametric testing and multiple regression to investigate associations between brain metrics and psychological scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In primary analyses, individuals with AN exhibited a significant reduction in precuneus CTh only. Precuneus CTh correlated negatively with EDI\u2010II, BAI, and BDI\u2010II scores, and positively with BMI\u2010SDS. Regression analysis identified anxiety (BAI), specific EDI\u2010II subscales, supra\u2010diaphragmatic autonomic reactivity and difficulties describing negative feelings (PAQ) as predictors of precuneus CTh. Exploratory analyses revealed thickness differences in parietal and frontal regions, consistent with prior large\u2010scale studies, with anxiety and depression scores correlating with several of these regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Reduced precuneus CTh and its association with psychological factors highlight its role in AN's neurobiological mechanisms. Exploratory findings implicate parietal and frontal alterations, suggesting broader disruptions in body perception and behavioral control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24591","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:20:36Z","timestamp":1762240836000},"page":"384-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relationship Between Precuneus Thickness and Psychopathology in Adolescent Females With Anorexia Nervosa"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8414-2895","authenticated-orcid":false,"given":"Irina","family":"Jarvers","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy University of Regensburg  Regensburg 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