{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:11:19Z","timestamp":1773335479681,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["32880"],"award-info":[{"award-number":["32880"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["F32 MH124409"],"award-info":[{"award-number":["F32 MH124409"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH101521"],"award-info":[{"award-number":["R01 MH101521"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH116205"],"award-info":[{"award-number":["R01 MH116205"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R37 MH068376"],"award-info":[{"award-number":["R37 MH068376"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Restrictive eating disorders (EDs), including anorexia nervosa (AN) and atypical AN (Atyp\u2010AN), are often associated with cognitive rigidity that can impede treatment. The dorsolateral prefrontal cortex (dlPFC) plays a central role in cognitive control, but it remains unclear whether its activation during cognitive flexibility will differ across restrictive ED presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010seven females with restrictive EDs (aged 14\u201335) (AN:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931; atyp\u2010AN with history of AN [hx\u2010AN]:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933; atyp\u2010AN without history of AN [Atyp\u2010AN]:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) completed a task\u2010switching paradigm during functional magnetic resonance imaging. We examined dlPFC activation during sustained (task\u2010switching vs. completing a single task) and transient control (switching between task rules vs. repeating the same rule), testing for group differences and symptom associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The AN group showed a greater difference in left dlPFC activation during task switching vs. the single task compared to the hx\u2010AN and Atyp\u2010AN groups, driven by reduced activation during the single task condition. All groups showed similar increases in dlPFC activation during task switching and no differences in task performance. Across all participants, higher dlPFC activation during task switching vs. single task was associated with greater restraint symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These novel findings identified shared versus unique neural features of sustained and transient control across restrictive ED groups. Heightened dlPFC activation during transient control associated with restraint may represent a transdiagnostic feature shared across restrictive EDs. Alternatively, reduced dlPFC activation during the low\u2010demand, single\u2010task condition in those with typical, but not atypical AN, may reflect a difference in sustained control, with implications for tailoring interventions to distinct restrictive ED presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.24599","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:33:19Z","timestamp":1762857199000},"page":"466-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared Versus Unique Features of Neural Activation During Cognitive Flexibility Across Restrictive Eating Disorder Presentations"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-0857","authenticated-orcid":false,"given":"Adrienne L.","family":"Romer","sequence":"first","affiliation":[{"name":"Department of Psychology Virginia Polytechnic Institute and State University  Blacksburg Virginia USA"},{"name":"Center for Depression, Anxiety, and Stress Research McLean Hospital  Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-6519","authenticated-orcid":false,"given":"Lauren","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Slattery","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Petterway","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Lindman","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Scott","sequence":"additional","affiliation":[{"name":"Center for Depression, Anxiety, and Stress Research McLean Hospital  Belmont Massachusetts USA"},{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Lauze","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Cravitz","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zara","family":"Poon","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddarth","family":"Seenivasa","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Naticchia","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"},{"name":"Department of Neuroscience Harvard University  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-2331","authenticated-orcid":false,"given":"Kristin N.","family":"Javaras","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Women's Mental Health McLean Hospital  Belmont Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Alperovitz","sequence":"additional","affiliation":[{"name":"Division of Women's Mental Health McLean Hospital  Belmont Massachusetts USA"},{"name":"Klarman Eating Disorders Center McLean Hospital  Belmont Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-581X","authenticated-orcid":false,"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Eating Disorders Clinical and Research Program, Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston 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