{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:03:32Z","timestamp":1788966212267,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH108595"],"award-info":[{"award-number":["R01MH108595"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH103403"],"award-info":[{"award-number":["R01MH103403"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K24MH120568"],"award-info":[{"award-number":["K24MH120568"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K24MH135189"],"award-info":[{"award-number":["K24MH135189"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH125143"],"award-info":[{"award-number":["K23MH125143"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH127465"],"award-info":[{"award-number":["K23MH127465"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23DK131334"],"award-info":[{"award-number":["K23DK131334"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005197","name":"Hilda and Preston Davis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001945","name":"American Psychological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Avoidant\/restrictive food intake disorder (ARFID) is characterized by limited dietary volume and\/or variety due to fear of aversive consequences, lack of interest in eating, and\/or sensory sensitivity. Uncontrolled studies suggest that cognitive\u2010behavioral therapy for ARFID (CBT\u2010AR) is beneficial, but neural mechanisms remain unknown. Prior work has shown hyperactivation in regions of the salience network (SN) during the presentation of food stimuli in ARFID compared to healthy controls, and the SN shows reduction from pre\u2010 to post\u2010CBT in anxiety disorders. We tested hypotheses that (1) higher pre\u2010treatment food\u2010related activation in the SN (anterior cingulate cortex [ACC], anterior insula, amygdala) would be prospectively associated with greater reductions in ARFID severity at post\u2010treatment, and (2) food\u2010related activation in the SN would decrease from pre\u2010 to post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In a validated functional magnetic resonance imaging (fMRI) food cue paradigm, youth with ARFID viewed images of food and non\u2010food in a fasted state at pre\u2010treatment (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200924) and a subset (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200914) also completed post\u2010treatment scans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pre\u2010treatment activation in response to food versus objects was not associated with changes in ARFID severity or remission post\u2010treatment. However, hyperactivation in the right ACC (MNI coordinates: 3, 53, 17;\n                      <jats:italic>k<\/jats:italic>\n                      (\n                      <jats:italic>E<\/jats:italic>\n                      )\u2009=\u2009579,\n                      <jats:italic>p<\/jats:italic>\n                      (FWE\n                      <jats:sub>corr<\/jats:sub>\n                      )\u2009=\u20090.013) decreased from pre\u2010 to post\u2010treatment with a large effect size (\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20091.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These pilot findings raise the possibility that changes in SN neural activity may be candidate mechanisms through which CBT\u2010AR exerts its effects. Randomized controlled trials are needed to replicate and extend these results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT02963220<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70062","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:00:41Z","timestamp":1773115241000},"page":"1506-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Exploratory Study of Neural Response to Food Cues Following Cognitive\u2010Behavioral Therapy for Avoidant\/Restrictive Food Intake Disorder"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-9977","authenticated-orcid":false,"given":"Kendra R.","family":"Becker","sequence":"first","affiliation":[{"name":"Eating Disorders Clinical 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Research Collaborative  Boston Massachusetts USA"},{"name":"Division of Women's Health, Department of Medicine, and Department of Psychiatry Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Neuroendocrine Unit  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4698-5175","authenticated-orcid":false,"given":"Abigail G.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8934-019X","authenticated-orcid":false,"given":"Rebecca","family":"Karlson","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-5395","authenticated-orcid":false,"given":"Lilian P.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-8667","authenticated-orcid":false,"given":"Casey","family":"Stern","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder 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P.","family":"Kristine Hauser","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Neuroendocrine Unit  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9405-2981","authenticated-orcid":false,"given":"Madhusmita","family":"Misra","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Neuroendocrine Unit  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-3349","authenticated-orcid":false,"given":"Elizabeth A.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Neuroendocrine Unit  Boston Massachusetts USA"},{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-0930","authenticated-orcid":false,"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-7789","authenticated-orcid":false,"given":"Laura","family":"Holsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"},{"name":"Division of Women's Health, Department of Medicine, and Department of Psychiatry Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-581X","authenticated-orcid":false,"given":"Jennifer J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"171","volume-title":"Fear and Anxiety: The Benefits of Translational Research","author":"Barlow D. 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