{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T09:03:52Z","timestamp":1780563832763,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This spotlight highlights a critical gap in the research literature. Despite evidence that combined cognitive\u2010behavioral therapy (CBT) and lisdexamfetamine dimesylate (LDX) for binge\u2010eating disorder (BED) is superior to either intervention alone, no studies have examined whether psychotherapy can support gradual tapering off LDX while preserving treatment gains. While evidence shows higher rates of binge\u2010eating relapse after LDX discontinuation, long\u2010term use is complicated by concerns regarding side effects (e.g., hypertension), misuse\u2010potential, cost, and\/or drug interactions. Unfortunately, without current research on optimal LDX tapering strategies, clinicians lack guidance at a critical juncture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Given the absence of studies that have examined tapering psychiatric medications in BED, let alone any established protocols for doing so, the authors offer two spotlighted examples to illustrate the potential utility and clinical challenges of therapist guided LDX discontinuation during psychotherapy for BED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The spotlighted examples demonstrate that binge relapse can be avoided through gradual LDX tapering embedded within psychotherapy, with treatment gains sustained at long\u2010term follow\u2010up (up to 5\u2009years after LDX discontinuation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This spotlight highlights the need for further research to investigate discontinuing LDX and whether gradual, therapist\u2010supported tapering might enable the superiority of combined treatment to be sustained. Spotlighted examples were used to illustrate the conceptual framework and clinical relevance of this spotlight's central argument: that systematically evaluating optimal approaches to medication discontinuation, specifically LDX for BED, is an idea worth researching. We describe potential obstacles and limitations while also highlighting clinical or policy implications for future study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70071","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:08:14Z","timestamp":1773007694000},"page":"1246-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychotherapy\u2010Supported Lisdexamfetamine Tapering in Binge\u2010Eating Disorder: Spotlighting a Critical Research Gap"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-1556","authenticated-orcid":false,"given":"Cristin D.","family":"Runfola","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9874-2277","authenticated-orcid":false,"given":"Debra L.","family":"Safer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010019\u20100034\u20103"},{"key":"e_1_2_10_3_1","volume-title":"Practice Guideline for the Treatment of Patients With Major Depressive Disorder","author":"American Psychiatric Association","year":"2010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2024.100333"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycom.2024.100195"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2024.02.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v68n0901"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/PY23046"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.23180001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115537"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199412)16:4<363::AID-EAT2260160405>3.0.CO;2-#"},{"key":"e_1_2_10_13_1","first-page":"361","volume-title":"Binge\u2010Eating: Nature, Assessment and Treatment","author":"Fairburn C. 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