{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:17:46Z","timestamp":1783012666158,"version":"3.54.6"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the role of maintenance mechanisms not specific to eating disorders, as conceptualized in enhanced cognitive behavioral therapy (CBT\u2010E)\u2014namely clinical perfectionism, low core self\u2010esteem, mood intolerance, and interpersonal problems\u2014in patients with anorexia nervosa receiving intensive focused CBT\u2010E. The aim was to assess changes in these mechanisms during treatment and their predictive value for outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this prospective cohort study, 113 patients aged 16\u201365\u2009years were admitted for intensive CBT\u2010E. Body mass index (BMI), eating disorder psychopathology, general psychopathology, and functional impairment were assessed at baseline, end of intensive treatment (EOIT), and 20\u2010week follow\u2010up. Non\u2010eating disorder\u2010specific variables were evaluated at baseline and EOIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010nine patients (87.6%) completed treatment, and 75 (75.8%) attended follow\u2010up. All non\u2010eating disorder\u2010specific mechanisms showed significant improvement during treatment. No variable predicted the dropout rate. In intention\u2010to\u2010treat analyses, lower self\u2010esteem at baseline predicted increased eating disorder psychopathology at EOIT, while lower self\u2010esteem at EOIT predicted increased psychopathology at follow\u2010up. Additionally, lower baseline sociability and interpersonal ambivalence at EOIT\u2014features of interpersonal problems\u2014predicted decreased BMI at EOIT and follow\u2010up, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The focused form of intensive CBT\u2010E is associated with significant improvements in non\u2010eating disorder specific mechanisms in patients with anorexia nervosa. However, when low self\u2010esteem or specific interpersonal difficulties are present, these factors significantly predict poorer outcomes in eating\u2010disorder psychopathology and weight restoration. This suggests that, for a subset of patients, addressing these non\u2010eating disorder specific mechanisms more directly may be necessary to optimize treatment response and sustain improvements over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70074","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:40:51Z","timestamp":1774496451000},"page":"1564-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transdiagnostic Predictors of Treatment Outcome in\u00a0Patients With Anorexia Nervosa Receiving Intensive Enhanced Cognitive Behavioral Therapy (\n                    <scp>CBT<\/scp>\n                    \u2010E)"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-1877","authenticated-orcid":false,"given":"Simona","family":"Calugi","sequence":"first","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-234X","authenticated-orcid":false,"given":"Anna","family":"Dalle Grave","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8413-1689","authenticated-orcid":false,"given":"Mirko","family":"Chimini","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0607-4606","authenticated-orcid":false,"given":"Gianmatteo","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9633-5918","authenticated-orcid":false,"given":"Maddalena","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-3721","authenticated-orcid":false,"given":"Riccardo","family":"Dalle Grave","sequence":"additional","affiliation":[{"name":"Department of Eating and Weight Disorders Villa Garda Hospital  Garda Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.23278"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.06.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24455"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17172731"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010016\u20100276\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519\u2010018\u20100477\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23067"},{"key":"e_1_2_10_10_1","volume-title":"Intensive Cognitive Behavior Therapy for Eating Disorders","author":"Dalle Grave R.","year":"2012"},{"key":"e_1_2_10_11_1","first-page":"231","volume-title":"Cognitive Behavior Therapy and Eating Disorders","author":"Dalle Grave R.","year":"2008"},{"key":"e_1_2_10_12_1","volume-title":"Cognitive Behavior Therapy for Adolescents With Eating Disorders","author":"Dalle Grave R.","year":"2020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350058"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044\u20108260.1993.tb01045.x"},{"key":"e_1_2_10_15_1","volume-title":"The Brief Symptom Inventory: Administration, Scoring and Procedures Manual","author":"Derogatis L. 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