{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:13:00Z","timestamp":1788347580409,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low\u2010calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in AN, such as selenium deficiency, are known to increase anxiety and the risk of suicide. Two large studies in adults highlighted frequent selenium and copper deficiencies; this information is lacking in children. The present study aimed to provide a comprehensive description of the micronutrient status in pediatric AN and evaluate whether deficiencies differ according to AN subtype (restricting, R, binge\u2010eating\/purging, BP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective, single\u2010center, descriptive study was conducted in a cohort of children with AN who were evaluated at a specialist eating disorders center from 2016 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample comprised 349 patients (mean age 14.7\u2009\u00b1\u20091.8\u2009years); 91.4% had AN\u2010R, 8.6% BP. Mean weight loss was 18.2%\u2009\u00b1\u200910.7%, and initial BMI was 16.7\u2009\u00b1\u20091.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      according to the International Obesity Task Force. At least one micronutrient deficiency was found in 90% of patients; 51.3% experienced multiple deficiencies. The most common were selenium (23.5%), copper (18.4%), and vitamin A (29.1%). The prevalence of deficiencies was similar between AN\u2010R and AN\u2010BP, except for potassium and calcium which were significantly lower in AN\u2010BP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Micronutrients deficiencies are frequent in pediatric AN with no difference according to subtype. The functional impact and the benefit of supplementation remain to be studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70120","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:45:37Z","timestamp":1779083137000},"page":"2004-2012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders"],"prefix":"10.1002","volume":"59","author":[{"given":"Zenaida","family":"Iordan","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"},{"name":"D\u00e9partement Femme M\u00e8re Enfant Service de P\u00e9diatrie, Centre Hospitalier Universitaire Vaudois  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Morfin","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bernetiere","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Fauchet","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl","family":"Peretti","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"},{"name":"Hospices Civils de Lyon, Service d'H\u00e9patologie, Gastro\u2010ent\u00e9rologie et Nutrition P\u00e9diatrique  Bron France"},{"name":"Laboratoire CarMeN, INSERM\u2010U1060, INRA\u2010U1397  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7926-0144","authenticated-orcid":false,"given":"B\u00e9r\u00e9nice","family":"Segrestin","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"},{"name":"Laboratoire CarMeN, INSERM\u2010U1060, INRA\u2010U1397  Pierre\u2010B\u00e9nite France"},{"name":"Centre de Recherche en Nutrition Humaine Rh\u00f4ne\u2010Alpes, INSERM, INRAE, Universit\u00e9 Claude Bernard Lyon 1, Hospices Civils de Lyon  Pierre B\u00e9nite France"},{"name":"Hospices Civils de Lyon, Service d'Endocrinologie, Diab\u00e9tologie et Nutrition  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Poinsot","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, Centre R\u00e9f\u00e9rent pour l'Anorexie Mentale et Les Troubles Des Conduites Alimentaires de Lyon  Bron France"},{"name":"Hospices Civils de Lyon, Service d'H\u00e9patologie, Gastro\u2010ent\u00e9rologie et Nutrition P\u00e9diatrique  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030225"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03325347"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.02.021"},{"key":"e_1_2_13_5_1","unstructured":"Alexandre P.2019.\u201cRecommandations Pour la Pratique Clinique D\u00e9finition Des \u00c9tats de D\u00e9nutrition (HAS 2019) Fiche Outil Diagnostic de la D\u00e9nutrition de L'enfant et de L'adulte \u201dHaute Autorit\u00e9 de Sant\u00e9\u00a0(HAS) Service Des Bonnes Pratiques Professionnelles F\u00e9d\u00e9ration Fran\u00e7aise De Nutrition (FFN) [Internet].https:\/\/www.has\u2010sante.fr\/."},{"key":"e_1_2_13_6_1","volume-title":"DSM\u20105\u2014Manuel Diagnostique et Statistique Des Troubles Mentaux|Elsevier Masson\u2014Livres, ebooks, Revues et Trait\u00e9s EMC Pour Toutes Sp\u00e9cialit\u00e9s M\u00e9dicales et Param\u00e9dicales","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20904"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091203"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2022.02.008"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(91)90251\u2010g"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000001027"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199404)15:3<251::AID-EAT2260150308>3.0.CO;2-#"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03327573"},{"issue":"5","key":"e_1_2_13_14_1","first-page":"627","article-title":"Dual Energy x\u2010Ray Absorptiometry Assessment of the Bone Mineral Content and Body Composition During Growth","volume":"83","author":"Braillon P. M.","year":"2002","journal-title":"Journal de Radiologie"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10079"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010020\u201000365\u20106"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042209"},{"key":"e_1_2_13_18_1","unstructured":"Courbes AFPA\u2010CRESS\/Inserm\u2010CompuGroup Medical.2018.\u201cNon Libres de Droit [Internet].\u201dhttps:\/\/afpa.org\/outil\/courbes\u2010de\u2010croissance\u2010garcons\u2010francais\/."},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2014.01.003"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh\u20102025\u20100116"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12066"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22289"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy342"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291724001697"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.991707"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/59.5.1223S"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092101"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040792"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2012.07.024"},{"key":"e_1_2_13_30_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9.2026.\u201cAnorexie Mentale: Prise en Charge [Internet].\u201dhttps:\/\/www.has\u2010sante.fr\/jcms\/c_985715\/fr\/anorexie\u2010mentale\u2010prise\u2010en\u2010charge."},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(95)00085\u20102"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.6.829"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26617"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113819"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.10.021"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1728"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002962\u2010z"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1402199"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.114231"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009384.pub2"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347094"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010022\u201000984\u20104"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22347"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005678"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117690528"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12354"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)02490\u20109"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.14091"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8010012"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610361478"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.017"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105723"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102017\u2010316304"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.187"},{"key":"e_1_2_13_55_1","volume-title":"Vitamin and Mineral Requirements in Human Nutrition","author":"World Health Organization","year":"2026"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017936"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:15:43Z","timestamp":1788344143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/eat.70120"],"URL":"https:\/\/doi.org\/10.1002\/eat.70120","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}