{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:13:12Z","timestamp":1788347592175,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge\u2010eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio\u2010behavioral phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Women with BED and co\u2010occurring major depressive disorder (BED+MDD;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) were compared to strictly matched controls with MDD alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938) to isolate BED\u2010specific effects. We analyzed the gut microbiome via 16S rRNA sequencing and assessed cardiac vagal tone using short\u2010term heart rate variability (specifically normalized high\u2010frequency power, HFnu). Nutritional intake was analyzed to explore diet\u2010microbiome interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While global diversity did not differ between groups, differential abundance analysis identified lower relative abundance of several fermentative taxa, including\n                      <jats:italic>Catenibacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Acidaminococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Pediococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Megasphaera<\/jats:italic>\n                      , and\n                      <jats:italic>Prevotella<\/jats:italic>\n                      in the BED group. Notably, a cross\u2010system association emerged exclusively in the BED group: the depletion of\n                      <jats:italic>Pediococcus<\/jats:italic>\n                      was strongly correlated with reduced vagal tone (HFnu;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and specific micronutrient patterns. This relationship was absent in the MDD\u2010only controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings demonstrate a BED\u2010specific link between the depletion of the fermentative guild, autonomic instability, and dietary energy intake. This linked state may reflect a physiological response to the acute substrate surges characteristic of binge\u2010eating, potentially compromising gut\u2010brain axis homeostasis. Future research incorporating direct measures of binge behavior and luminal environment is required to validate whether these microbial patterns represent a causal mechanism or a reproducible physiological marker of the disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70139","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:59:31Z","timestamp":1780289971000},"page":"2059-2075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Microbial Depletion and Autonomic Dysregulation in Binge\u2010Eating Disorder"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6996-0475","authenticated-orcid":false,"given":"Shuang","family":"Liang","sequence":"first","affiliation":[{"name":"School of Psychology and Counselling, Faculty of Health, QUT  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-6395","authenticated-orcid":false,"given":"Esben","family":"Strodl","sequence":"additional","affiliation":[{"name":"School of Psychology and Counselling, Faculty of Health, QUT  Brisbane Queensland Australia"},{"name":"QUT Eating Disorder Clinic  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-5540","authenticated-orcid":false,"given":"Leanne","family":"Barron","sequence":"additional","affiliation":[{"name":"QUT Eating Disorder Clinic  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-5184","authenticated-orcid":false,"given":"Matthew","family":"Bambling","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7490-9298","authenticated-orcid":false,"given":"Luis","family":"Vitetta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"ADInstruments.2024.\u201cLabChart\u00a08 (Version 8.x).\u201dhttps:\/\/www.adinstruments.com."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010025\u201001014\u2010y"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13050482"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144563"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"3","key":"e_1_2_13_7_1","article-title":"Core Symptoms of Eating Disorders and Heart Rate Variability: A Systematic Review","volume":"7","author":"\u00c1vila A.","year":"2025","journal-title":"Sciences"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010012\u20100302\u2010z"},{"key":"e_1_2_13_9_1","volume-title":"Manual for the Beck Depression Inventory\u2010II","author":"Beck A. T.","year":"1996"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00508\u201007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2004.03508.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136803"},{"issue":"9","key":"e_1_2_13_13_1","article-title":"The Gut Microbiome in Human Obesity: A Comprehensive Review","volume":"13","author":"Borrego\u2010Ruiz A.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010025\u201001092\u20106"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy119"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.272"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2018"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00768"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.016"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000750"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.009"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.09.005"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010321747"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiac038"},{"key":"e_1_2_13_27_1","unstructured":"First M. B. J. B.Williams R. S.Karg andR. L.Spitzer.2015.\u201cStructured Clinical Interview for DSM\u20105 Disorders. Research Version (SCID\u20105\u2010RV).\u201d"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13102244"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.156"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2016.11.007"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.04.014"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000344\u2010y"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.11.009"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1108\/rr\u201010\u20102013\u20100256"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2357177"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.006937"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01823"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482\u2010026\u201002283\u20100"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04609.x"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010025\u201001237\u2010z"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00392"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010022\u201001318\u20103"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010024\u201005943\u20105"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2023.100579"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00213"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2012.08.005"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281951"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v15.i7.105249"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010024\u201000887\u20109"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017\u201012607"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.17113\/ftb.61.02.23.7929"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2009.03.005"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13467"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2418415"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071573"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2024.1415567"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11030415"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1017\/gmb.2023.18"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080818"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.08.009"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21123998"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02443\u201012"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519000680"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14126"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.10.001"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11123038"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(14)00051\u20100"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2024.104088"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114525103462"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(02)07605\u20105"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12100895"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201071093\u2010z"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105701"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.syapm.2016.05.003"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010021\u201000559\u2010y"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23291"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.7.3692\u20103700.2005"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003580\u20107"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2024.9250305"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105317714318"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114366"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.01.026"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2019.121464"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.07.023"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:16:00Z","timestamp":1788344160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/eat.70139"],"URL":"https:\/\/doi.org\/10.1002\/eat.70139","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}