{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:47:08Z","timestamp":1782920828892,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["3166\u201000028B"],"award-info":[{"award-number":["3166\u201000028B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity and increased relative mortality compared to the general population. Involuntary treatment (IT) is implemented after exhausting voluntary treatment options. This study investigates mortality in patients with AN following IT, using IT as an indicator of patient vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A register\u2010based cohort study including individuals diagnosed with AN (ICD\u201010: F50.0, F50.1) from 2000 to 2016 at any Danish hospital and with an inpatient admission following their AN diagnosis. The exposure was the first instance of any IT event and categories of IT after AN. IT could be associated with AN or any other diagnosis. The outcome was mortality; all\u2010cause and divided into deaths from diseases and medical conditions, external causes, or suicide. Excess mortality was estimated as hazard ratios (HR) using Cox proportional hazards regression. The model was adjusted for sex, age at AN diagnosis, birth year, prior IT, self\u2010harm, and other psychiatric morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the study period 4425 individuals (93.3% female; mean age at diagnosis\u2009=\u200922, SD\u2009=\u200912) were included in the study. Of these, 821 individuals received IT (18.5%) and 206 individuals (4.7%) died. The HRs were elevated for all\u2010cause mortality (HR\u2009=\u20092.21, [95% CI: 1.54\u20133.17]), external causes (HR\u2009=\u20093.88, [95% CI: 1.94\u20137.77]), and suicide (HR\u2009=\u20095.30, [95% CI: 2.07\u201313.54]). The analysis of IT categories only showed an elevated HR for electroconvulsive therapy and somatic concerns (HR\u2009=\u20091.96, [95%\u00a0CI: 1.04\u20133.67]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite IT primarily being used to safeguard the life of the most vulnerable patients, mortality for those who received IT was elevated. The results indicate that this patient group requires sustained clinical attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70166","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:06:16Z","timestamp":1782918376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Excess Mortality Among Patients With Anorexia Nervosa Treated Involuntarily"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-2808","authenticated-orcid":false,"given":"Line","family":"Bager","sequence":"first","affiliation":[{"name":"NCRR, National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0232-855X","authenticated-orcid":false,"given":"Katrine","family":"Holde","sequence":"additional","affiliation":[{"name":"NCRR, National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-1017","authenticated-orcid":false,"given":"Janne Tidselbak","family":"Larsen","sequence":"additional","affiliation":[{"name":"NCRR, National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-8347","authenticated-orcid":false,"given":"Loa","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Child and Adolescent Psychiatry Aarhus University Hospital Psychiatry  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-1596","authenticated-orcid":false,"given":"Zeynep","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"NCRR, National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus Universit  Aarhus Denmark"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-3642","authenticated-orcid":false,"given":"Benjamin","family":"Mac Donald","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Aarhus University Hospital Psychiatry  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-5379","authenticated-orcid":false,"given":"Liselotte Vogdrup","family":"Petersen","sequence":"additional","affiliation":[{"name":"NCRR, National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"CIRRAU, Centre for Integrated Register\u2010Based Research, Aarhus University  Aarhus 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Insights and Risk Factors of Involuntary Hospitalizations Through a Retrospective Analysis of Police Records: Differences Between Involuntarily and Non\u2010Hospitalized Patients \u201d(2016)."},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijlp.2009.10.003"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010024\u201001120\u2010x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30059\u20103"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010019\u20104658\u20100"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000739"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22377"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2020.79"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12361"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/1.4.423"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.70166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:06:26Z","timestamp":1782918386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.70166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":43,"alternative-id":["10.1002\/eat.70166"],"URL":"https:\/\/doi.org\/10.1002\/eat.70166","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eat.70166"}}