{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:13:50Z","timestamp":1783653230129,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["20257983"],"award-info":[{"award-number":["20257983"]}],"id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["259764"],"award-info":[{"award-number":["259764"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["Y221"],"award-info":[{"award-number":["Y221"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Eating Disorders"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Neurodevelopmental conditions frequently co\u2010occur with eating disorders (EDs). This study aimed to investigate the occurrence of attention\u2010deficit\/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), tic disorder (TD), and obsessive\u2010compulsive disorder (OCD) in individuals with EDs and their full and half siblings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Study population comprised all individuals born in Finland between 1991 and 2001 with a recorded diagnosis of the following ICD\u201010 EDs (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094240): anorexia nervosa (AN; F50.0\/F50.1), bulimia nervosa (BN; F50.2\/F50.3), and other\/unspecified EDs (F50.8\/F50.9). Population controls without ED (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200916,494) and full and half siblings of participants with ED and controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200936,301) were included. Conditional logistic regression was applied in analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals with AN had increased occurrence of ASD, ADHD, and OCD compared to population controls (Odds ratios [ORs]: 6.62 [95% CI 4.21\u201310.39]; 3.30 [95% CI 2.33\u20134.69]; 10.67 [95% CI 7.07\u201316.10], respectively). Individuals with other\/unspecified EDs had increased occurrence of ASD, ADHD, TD, and OCD (ORs: 9.06 [95% CI 5.5\u201314.77]; 2.78 [95% CI 1.92\u20134.01]; 4.68 [95% CI 1.94\u201311.32]; 7.64 [95% CI 4.92\u201311.87], respectively). The occurrence for ASD was particularly pronounced in males with other\/unspecified EDs (OR 32.40 [95% CI 9.78\u2013107.39]). Compared to full siblings of population controls, full siblings of individuals with AN had two\u2010fold odds for ASD and three\u2010fold odds for OCD; full siblings of individuals with other\/unspecified EDs had 2\u20133\u2010fold odds for ASD, ADHD, TD, and OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Individuals with EDs have a high occurrence of neurodevelopmental conditions, also extending to their full siblings. These findings provide detailed characterization of comorbidity and the familial aggregation of these conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/eat.70171","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:27:21Z","timestamp":1783650441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autism Spectrum Disorder, Attention\u2010Deficit\/Hyperactivity Disorder, Tic Disorder, and Obsessive\u2010Compulsive Disorder in Individuals With Eating Disorders and Their Siblings: A Nationwide Finnish Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-554X","authenticated-orcid":false,"given":"Emma","family":"Saure","sequence":"first","affiliation":[{"name":"Clinicum, Department of Psychiatry University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-8151","authenticated-orcid":false,"given":"Pyry N.","family":"Sipil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-9196","authenticated-orcid":false,"given":"Susanna","family":"Hinkka\u2010Yli\u2010Salom\u00e4ki","sequence":"additional","affiliation":[{"name":"Research Centre for Child Psychiatry, INVEST Flagship University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-7244","authenticated-orcid":false,"given":"Andre","family":"Sourander","sequence":"additional","affiliation":[{"name":"Research Centre for Child Psychiatry, INVEST Flagship University of Turku  Turku Finland"},{"name":"Department of Child Psychiatry Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2637-0818","authenticated-orcid":false,"given":"Elina","family":"Santti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Adolescent Psychiatry Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-9441","authenticated-orcid":false,"given":"Anu","family":"Raevuori","sequence":"additional","affiliation":[{"name":"Clinicum, Department of Psychiatry University of Helsinki  Helsinki Finland"},{"name":"Department of Psychiatry, Division of Adolescent Psychiatry Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8757"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010020\u201004479\u20103"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20251"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204516"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002825\u2010w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojepi.2013.34028"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010019\u20100251\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010020\u201001189\u2010w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.10.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11070912"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2019.05.012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009820\u20103"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22733"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23481"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2244"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010014\u20102336\u2010y"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24307"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23991"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000896"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.153221"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.668297"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.020"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201061496\u20105"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000911"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22823"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337\u2010021\u201000518\u20101"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.14134"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000113"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000742"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100320\u20100"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2019.01.003"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2021.105713"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23570"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2701"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.24532"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.01.083"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.10.016"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20101955"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.04.036"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719002976"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100115\u20104"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2941"}],"container-title":["International Journal of Eating Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/eat.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/eat.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:27:22Z","timestamp":1783650442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eat.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":42,"alternative-id":["10.1002\/eat.70171"],"URL":"https:\/\/doi.org\/10.1002\/eat.70171","archive":["Portico"],"relation":{},"ISSN":["0276-3478","1098-108X"],"issn-type":[{"value":"0276-3478","type":"print"},{"value":"1098-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eat.70171"}}