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We developed five connected, standards\u2010aligned yeast evolution laboratory modules, called \u201cyEvo,\u201d for high school students. The modules enable students to take agency in answering open\u2010ended research questions. In Module 1, students evolve baker's yeast to tolerate an antifungal drug, and in subsequent modules, investigate how evolved yeasts adapted to this stressful condition at both the phenotype and genotype levels. We used pre\u2010 and post\u2010surveys from 72 students at two different schools and post\u2010interviews with students and teachers to assess our program goals and guide module improvement over 3\u2009years. We measured changes in student conceptions, confidence in scientific practices, and interest in STEM careers. Students who participated in yEvo showed improvements in understanding of activity\u2010specific concepts and reported increased confidence in designing a valid biology experiment. Student experimental data replicated literature findings and has led to new insights into antifungal resistance. The modules and provided materials, alongside \u201cproof of concept\u201d evaluation metrics, will serve as a model for other university researchers and K\u2009\u2212\u200916 classrooms interested in engaging in open\u2010ended research questions using yeast as a model system.<\/jats:p>","DOI":"10.1002\/ece3.10811","type":"journal-article","created":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T20:39:20Z","timestamp":1704659960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["yEvo: A modular eukaryotic genetics and evolution research experience for high school students"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-6467","authenticated-orcid":false,"given":"M. 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