{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:25:52Z","timestamp":1791505552225,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["105624"],"award-info":[{"award-number":["105624"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/J007064\/1"],"award-info":[{"award-number":["NE\/J007064\/1"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The evolution of host\u2013parasite interactions could be affected by intraspecies variation between different host and parasite genotypes. Here we studied how bacterial host cell\u2010to\u2010cell signaling affects the interaction with parasites using two bacteria\u2010specific viruses (bacteriophages) and the host bacterium <jats:italic>Pseudomonas aeruginosa<\/jats:italic> that communicates by secreting and responding to quorum sensing (<jats:styled-content style=\"fixed-case\">QS<\/jats:styled-content>) signal molecules. We found that a <jats:styled-content style=\"fixed-case\">QS<\/jats:styled-content>\u2010signaling proficient strain was able to evolve higher levels of resistance to phages during a short\u2010term selection experiment. This was unlikely driven by demographic effects (mutation supply and encounter rates), as nonsignaling strains reached higher population densities in the absence of phages in our selective environment. Instead, the evolved nonsignaling strains suffered relatively higher growth reduction in the absence of the phage, which could have constrained the phage resistance evolution. Complementation experiments with synthetic signal molecules showed that the <jats:italic>Pseudomonas<\/jats:italic> quinolone signal (<jats:styled-content style=\"fixed-case\">PQS<\/jats:styled-content>) improved the growth of nonsignaling bacteria in the presence of a phage, while the activation of <jats:italic>las<\/jats:italic> and <jats:italic>rhl<\/jats:italic> quorum sensing systems had no effect. Together, these results suggest that <jats:styled-content style=\"fixed-case\">QS<\/jats:styled-content>\u2010signaling can promote the evolution of phage resistance and that the loss of <jats:styled-content style=\"fixed-case\">QS<\/jats:styled-content>\u2010signaling could be costly in the presence of phages. Phage\u2013bacteria interactions could therefore indirectly shape the evolution of intraspecies social interactions and <jats:styled-content style=\"fixed-case\">PQS<\/jats:styled-content>\u2010mediated virulence in <jats:italic>P.\u00a0aeruginosa<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ece3.2818","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T04:06:40Z","timestamp":1487736400000},"page":"1936-1941","source":"Crossref","is-referenced-by-count":27,"title":["Bacterial cell\u2010to\u2010cell signaling promotes the evolution of resistance to parasitic bacteriophages"],"prefix":"10.1002","volume":"7","author":[{"given":"Pierre","family":"Moreau","sequence":"first","affiliation":[{"name":"Imperial College London, Silwood Park Campus  Ascot Berkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Diggle","sequence":"additional","affiliation":[{"name":"School of Life Sciences Centre for Biomolecular Sciences 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