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The transmission of these \u201czoonotic\u201d pathogens is affected by the abundance and behavior of their wildlife hosts. However, the effects of infection with zoonotic pathogens on behavior of wildlife hosts, particularly those that might propagate through ecological communities, are not well understood. <jats:italic>Borrelia burgdorferi<\/jats:italic> is a bacterium that causes Lyme disease, the most common vector\u2010borne disease in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and Europe. In its North American range, the pathogen is most frequently transmitted among hosts through the bite of infected blacklegged ticks (<jats:italic>Ixodes scapularis<\/jats:italic>). Using sham and true vaccines, we experimentally manipulated infection load with this zoonotic pathogen in its most competent wildlife reservoir host, the white\u2010footed mouse, <jats:italic>Peromyscus leucopus<\/jats:italic>, and quantified the effects of infection on mouse foraging behavior, as well as levels of mouse infestation with ticks. Mice treated with the true vaccine had 20% fewer larval blacklegged ticks infesting them compared to mice treated with the sham vaccine, a significant difference. We observed a nonsignificant trend for mice treated with the true vaccine to be more likely to visit experimental foraging trays (20%\u201330% effect size) and to prey on gypsy moth pupae (5%\u201320% effect size) compared to mice treated with the sham vaccine. We observed no difference between mice on true\u2010 versus sham\u2010vaccinated grids in risk\u2010averse foraging. Infection with this zoonotic pathogen appears to elicit behavioral changes that might reduce self\u2010grooming, but other behaviors were affected subtly or not at all. High titers of <jats:italic>B.\u00a0burgdorferi<\/jats:italic> in mice could elicit a self\u2010reinforcing feedback loop in which reduced grooming increases tick burdens and hence exposure to tick\u2010borne pathogens.<\/jats:p>","DOI":"10.1002\/ece3.3961","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T05:35:54Z","timestamp":1522128954000},"page":"4074-4083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of a zoonotic pathogen, <i>Borrelia burgdorferi<\/i>, on the behavior of a key reservoir host"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-9301","authenticated-orcid":false,"given":"Richard S.","family":"Ostfeld","sequence":"first","affiliation":[{"name":"Cary Institute of Ecosystem Studies  Millbrook NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin","family":"Brisson","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Oggenfuss","sequence":"additional","affiliation":[{"name":"Cary Institute of Ecosystem Studies  Millbrook NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Devine","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Z.","family":"Levy","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Keesing","sequence":"additional","affiliation":[{"name":"Bard College  Annandale\u2010on\u2010Hudson NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.2.419"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1202.050651"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-011112-112140"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.028738"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2007.1208"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00395696"},{"key":"e_1_2_8_8_1","first-page":"301","article-title":"Patch use under predation risk: I. 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