{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:20:16Z","timestamp":1777393216291,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009550","name":"Universiteit Hasselt","doi-asserted-by":"publisher","award":["BOF20KVU06"],"award-info":[{"award-number":["BOF20KVU06"]}],"id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>Hosts are typically coinfected by multiple parasite species whose interactions might be synergetic or antagonistic, producing unpredictable physiological and pathological impacts on the host. This study shows the interaction between <jats:italic>Plasmodium<\/jats:italic> spp. and <jats:italic>Leucocytozoon<\/jats:italic> spp. in birds experimentally infected or not infected with <jats:italic>Mycoplasma gallisepticum<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>In 1994, the bacterium <jats:italic>Mycoplasma gallisepticum<\/jats:italic> jumped from poultry to wild birds in which it caused a major epidemic in North America. Birds infected with <jats:italic>M<\/jats:italic>.\u00a0<jats:italic>gallisepticum<\/jats:italic> show conjunctivitis as well as increased levels of corticosterone.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Malaria and other haemosporidia are widespread in birds, and chronic infections become apparent with the detectable presence of the parasite in peripheral blood in response to elevated levels of natural or experimental corticosterone levels.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Knowing the immunosuppressive effect of corticosterone on the avian immune system, we tested the hypothesis that chronic infections of <jats:italic>Plasmodium<\/jats:italic> spp. and <jats:italic>Leucocytozoon<\/jats:italic> spp. in house finches would respond to experimental inoculation with <jats:italic>M.\u00a0gallisepticum<\/jats:italic> as corticosterone levels are known to increase following inoculation.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p><jats:italic>Plasmodium<\/jats:italic> spp. infection intensity increased within days of <jats:italic>M.\u00a0gallisepticum<\/jats:italic> inoculation as shown both by the appearance of infected erythrocytes and by the increase in the number and the intensity of positive PCR tests.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p><jats:italic>Leucocytozoon<\/jats:italic> spp. infection intensity increased when <jats:italic>Plasmodium<\/jats:italic> spp. infection intensity increased, but not in response to <jats:italic>M.\u00a0gallisepticum<\/jats:italic> inoculation. <jats:italic>Leucocytozoon<\/jats:italic> spp. and <jats:italic>Plasmodium<\/jats:italic> spp. seemed to compete in the host as shown by a negative correlation between the changes in their PCR score when both pathogens were present in the same individual.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Host responses to coinfection with multiple pathogens measured by the hematocrit and white blood cell count depended on the haemosporidian community composition. Host investment in the leukocyte response was higher in the single\u2010haemosporidia\u2010infected groups when birds were infected with <jats:italic>M.\u00a0gallisepticum<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>A trade\u2010off was observed between the immune control of the chronic infection (<jats:italic>Plasmodium<\/jats:italic> spp.<jats:italic>\/Leucocytozoon<\/jats:italic> spp.) and the immune response to the novel bacterial infection (<jats:italic>M.\u00a0gallisepticum<\/jats:italic>).<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1002\/ece3.6318","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T02:46:36Z","timestamp":1588214796000},"page":"5801-5814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Complex interactions between bacteria and haemosporidia in coinfected hosts: An experiment"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-6073","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Reinoso\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Natural Resources Cornell University Ithaca New York"},{"name":"Laboratory of Ornithology Cornell University Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keila V.","family":"Dhondt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology College of Veterinary Medicine Cornell University Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes V.","family":"Sydenstricker","sequence":"additional","affiliation":[{"name":"Department of Integrative Neurosciences Binghamton University Binghamton New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-8007","authenticated-orcid":false,"given":"Dieter","family":"Heylen","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology Princeton University Princeton New Jersey"},{"name":"Interuniversity Institute for Biostatistics and statistical Bioinformatics Hasselt University Diepenbeek Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-1401","authenticated-orcid":false,"given":"Andr\u00e9 A.","family":"Dhondt","sequence":"additional","affiliation":[{"name":"Laboratory of Ornithology Cornell University Ithaca New York"},{"name":"Department of Ecology and Evolutionary Biology Cornell University Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277599"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2009.02692.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2000.1181"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(92)90104-A"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.12578"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200001698X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10393-013-0852-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.01.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijppaw.2017.03.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.01.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2656.2012.01986.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-34.2.265"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.09.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-142"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/656496"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0301.970110"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2140"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1650\/0010-5422(2006)108[459:DQAAOA]2.0.CO;2"},{"key":"e_1_2_10_20_1","volume-title":"Laboratory medicine: Avian and exotic pets","author":"Fudge A. 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