{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:10:11Z","timestamp":1792131011504,"version":"4.4.0"},"reference-count":88,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1182"],"award-info":[{"award-number":["CRC 1182"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG 2501"],"award-info":[{"award-number":["RTG 2501"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["755659"],"award-info":[{"award-number":["755659"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Transgenerational immune priming (TGIP) adjusts offspring's immune responses based on parental immunological experiences. It is predicted to be adaptive when parent\u2013offspring environmental conditions match, while mismatches negate those advantages, rendering TGIP potentially costly. We tested these cost\u2013benefit dynamics in the pipefish\n                    <jats:italic>Syngnathus typhle<\/jats:italic>\n                    (Syngnathidae). Because of their unique male pregnancy, egg production and rearing occur in different sexes, providing both parents multiple avenues for TGIP. Parental bacteria exposure in our pipefish was simulated through vaccinations with heat\u2010killed\n                    <jats:italic>Vibrio aestuarianus<\/jats:italic>\n                    before mating the fish to each other or to controls. The resulting offspring were exposed to\n                    <jats:italic>V. aestuarianus<\/jats:italic>\n                    in control or heat stress environments, after which transcriptome and microbiome compositions were investigated. Transcriptomic TGIP effects were only observed in\n                    <jats:italic>Vibrio<\/jats:italic>\n                    \u2010exposed offspring at control temperatures, arguing for low costs of TGIP in non\u2010matching microbiota environments. Transcriptomic phenotypes elicited by maternal and paternal TGIP had limited overlap and were not additive. Parentally induced transcriptomic responses were associated with immune functions, and specifically, the paternal response to the innate immune branch, possibly hinting at trained immunity. TGIP of both parents reduced the relative abundance of the experimental\n                    <jats:italic>Vibrio<\/jats:italic>\n                    in exposed offspring, showcasing its ecological benefits. Despite TGIP's significance in matching biotic environments, no TGIP\u2010associated phenotypes were observed for heat\u2010treated offspring, illustrating its limitations. Heat spikes caused by climate change thus threaten TGIP benefits, potentially increasing susceptibility to emerging marine diseases. We demonstrate the urgent need to understand how animals cope with climate\u2010induced changes in microbial assemblages to assess their vulnerability in light of climate change.\n                  <\/jats:p>","DOI":"10.1002\/ece3.70552","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T05:41:33Z","timestamp":1732513293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Parent\u2010Specific Transgenerational Immune Priming Enhances Offspring Defense\u2014Unless Heat Stress Negates It All"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-7219","authenticated-orcid":false,"given":"Ralf F.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Zoology, Marine Evolutionary Biology University of Kiel  Kiel Germany"},{"name":"Department of Marine Evolutionary Ecology Helmholtz Centre for Ocean Research  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-5475","authenticated-orcid":false,"given":"Arseny","family":"Dubin","sequence":"additional","affiliation":[{"name":"Department of Zoology, Marine Evolutionary Biology University of Kiel  Kiel Germany"},{"name":"Department of Marine Evolutionary Ecology Helmholtz Centre for Ocean Research  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke\u2010Mareike","family":"Marten","sequence":"additional","affiliation":[{"name":"Department of Zoology, Marine Evolutionary Biology University of Kiel  Kiel Germany"},{"name":"Department of Marine Evolutionary Ecology Helmholtz Centre for Ocean Research  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-7797","authenticated-orcid":false,"given":"Olivia","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Zoology, Marine Evolutionary Biology University of Kiel  Kiel Germany"},{"name":"Department of Marine Evolutionary Ecology Helmholtz Centre for Ocean Research  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00555"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.12.049"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.726795"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01383\u201021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2021.729194"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201037026\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.2391"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2016.06.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-017-0885-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2012.08.028"},{"key":"e_1_2_10_12_1","unstructured":"Bisanz J. E.2018.\u201cqiime2R: Importing QIIME2 Artifacts and Associated Data Into R Sessions.\u201dVersion 0.99 13."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.005951"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2020.04.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010marine\u2010022123\u2010101845"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2023.111059"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2010.08.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1832-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010022\u201001280\u20105"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333946"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175659"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2020.0112"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2021.626442"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00248\u2010018\u20101242\u20109"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.02.014"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0137"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1138"},{"key":"e_1_2_10_31_1","unstructured":"Hothorn T. F.Bretz P.Westfall et\u00a0al.2016.\u201cPackage \u2018multcomp\u2019.\u201dSimultaneous Inference in General Parametric Models. Project for Statistical Computing Vienna Austria."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0653-x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.11.050"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1989.tb04247.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.24956.2"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.01.005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.03.001"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10071083"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2004.09.006"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2016.03.008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.094474"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201009159\u20104"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.13458"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmarsys.2021.103574"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100285\u20106"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00446"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13331"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","unstructured":"Pappert F. A. D.Kolbe A.Dubin andO.Roth.2023.\u201cThe Effect of Parental Age on the Quantity and Quality of Offspring inSyngnathus typhle a Species with Male Pregnancy.\u201dbioRxiv 2023.06.12.544574.https:\/\/doi.org\/10.1101\/2023.06.12.544574.","DOI":"10.1101\/2023.06.12.544574"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2024.105136"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.0184"},{"key":"e_1_2_10_52_1","volume-title":"Mixed\u2010Effects Models in S and S\u2010PLUS","author":"Pinheiro J.","year":"2006"},{"key":"e_1_2_10_53_1","unstructured":"Pinheiro J. D.Bates andR Core Team.2013.\u201cnlme: Linear and Nonlinear Mixed Effects Models.\u201dhttps:\/\/CRAN.R\u2010project.org\/package=nlme."},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2021.104245"},{"key":"e_1_2_10_55_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101766108"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00227\u2010021\u201003963\u20103"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ecolsys.27.1.451"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41437\u2010018\u20100101\u20102"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102656.2009.01617.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558\u20105646.2012.01614.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1086\/668081"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12473"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420\u20109101.2011.02273.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916251117"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00830"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12946"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2005.0369"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.15163"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198832140.001.0001"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.13880"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","unstructured":"Schneider R. F. J. M.Woltering D.Adriaens andO.Roth.2022.\u201cA Comparative Analysis of the Ontogeny of Syngnathids (Pipefishes & Seahorses) Reveals How Heterochrony Contributed to Their Diversification.\u201dbioRxiv 2022\u201308.https:\/\/doi.org\/10.1101\/2022.08.08.503137.","DOI":"10.1101\/2022.08.08.503137"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2017.03.001"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.12280"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013589\u20101"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2022.959830"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5347(96)10039-2"},{"key":"e_1_2_10_78_1","unstructured":"Signorell A. K.Aho A.Alfons et\u00a0al.2023.\u201cDescTools: Tools for Descriptive Statistics (Version 0.99.48) [Computer Software].\u201dhttps:\/\/CRAN.R\u2010project.org\/package=DescTools."},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024719\u2010z"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102656.12289"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","unstructured":"Tanger I. S. J.Stefanschitz Y.Schwert andO.Roth.2023.\u201cThe Source of Microbial Transmission Influences Niche Colonization and Microbiome Development.\u201dbioRxiv 2023.01.31.526426.https:\/\/doi.org\/10.1101\/2023.01.31.526426.","DOI":"10.1101\/2023.01.31.526426"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2023.2036"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eoac021"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01938"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.038034"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010019\u20103059\u2010z"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12862\u2010017\u20100930\u20102"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396\u2010019\u20100413\u20100"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2004.09.005"}],"container-title":["Ecology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.70552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ece3.70552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.70552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:38:01Z","timestamp":1780457881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ece3.70552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":88,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ece3.70552"],"URL":"https:\/\/doi.org\/10.1002\/ece3.70552","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.29.587316","asserted-by":"object"}]},"ISSN":["2045-7758","2045-7758"],"issn-type":[{"value":"2045-7758","type":"print"},{"value":"2045-7758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70552"}}