{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:51:14Z","timestamp":1789624274605,"version":"build-2803163510"},"reference-count":79,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["FR\u20102020\/0008"],"award-info":[{"award-number":["FR\u20102020\/0008"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201004251"],"award-info":[{"award-number":["2019\u201004251"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The lack of a fitness\u2010based theory of micronutrient allocation to specific tissues hinders understanding of the ultimate causes of mass juvenile mortality due to thiamine (vitamin B1) deficiency, which is an emerging threat to marine and coastal ecosystems worldwide. We modeled the optimal allocation of thiamine in salmon to somatic and reproductive tissues to investigate correlations between tissue thiamine levels, adult mortality, juvenile recruitment, and excretion rates that change with thiamine concentration. The model showed a positive correlation between thiamine levels in gonads and muscles, with a slope that increased with time. This was driven by a constrained thiamine input in salmon, but a negative or no correlation was found in scenarios with high thiamine input. These predictions were confirmed by analysis of empirical data from Atlantic salmon (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salmo salar<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) populations that differ in the occurrence of episodic thiamine deficiency. A positive correlation was indicative of low thiamine input, regardless of how juvenile recruitment and adult survival increased with thiamine concentration. The model output suggests that renal (i.e., kidney) reuptake is fundamental to understanding micronutrient allocation strategies. Measuring correlations between micronutrient concentrations in reproductive and somatic tissues of adults may help to detect early signs of thiamine deficiency before mass mortality of juveniles occurs. This can complement the previously suggested tissue concentrations and food web indicators. Future studies should try to distinguish and quantify the factors that alter the net thiamine input in salmonids and the subsequent allocation to offspring. Particular attention should be given to changes in thiamine uptake from the diet, including intestinal uptake mechanisms and\u00a0effects of thiaminase activity. Additionally, more information is needed on internal factors that reduce thiamine availability, such as thiamine degradation as an antioxidant during lipid metabolism, and other physiological factors that can potentially increase thiamine loss, including allocation mechanisms and renal processes.\n                  <\/jats:p>","DOI":"10.1002\/ece3.72339","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:32:54Z","timestamp":1760643174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Physiological Mechanisms and Life History Trade\u2010Offs in Salmonids Shape In\u2010Tissue Correlations of an Essential Micronutrient"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-4578","authenticated-orcid":false,"given":"Maciej Jan","family":"Ejsmond","sequence":"first","affiliation":[{"name":"Department of Biosciences, Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"},{"name":"Centre for Ecology of Microbial Model Systems Linnaeus University  Kalmar Sweden"},{"name":"Institute of Environmental Sciences Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0327-9547","authenticated-orcid":false,"given":"Vittoria","family":"Todisco","sequence":"additional","affiliation":[{"name":"Centre for Ecology of Microbial Model Systems Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2201-4416","authenticated-orcid":false,"given":"Marc M.","family":"Hauber","sequence":"additional","affiliation":[{"name":"Centre for Ecology of Microbial Model Systems Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-2284","authenticated-orcid":false,"given":"Kjetil","family":"Hindar","sequence":"additional","affiliation":[{"name":"Norwegian Institute for Nature Research  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3740-5998","authenticated-orcid":false,"given":"Samuel","family":"Hylander","sequence":"additional","affiliation":[{"name":"Centre for Ecology of Microbial Model Systems Linnaeus University  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"82","volume-title":"Early Life Stage Mortality Syndrome in Fishes of the Great Lakes and Baltic Sea. Proceedings of the 126th Annual Meeting of the American Fisheries Society","author":"Amcoff P.","year":"1998"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38821"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902903106"},{"key":"e_1_2_9_5_1","first-page":"2","article-title":"Reproductive Disturbances in Baltic Fish: A Synopsis of the FiRe Project","volume":"28","author":"Bengtsson B.\u2010E.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00351.2003"},{"key":"e_1_2_9_7_1","first-page":"73","article-title":"Thiamine Analysis in Fish Tissues","volume":"21","author":"Brown S. B.","year":"1998","journal-title":"American Fisheries Society Symposium"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195122664.001.0001"},{"key":"e_1_2_9_9_1","volume-title":"The Vitamins","author":"Combs G. F.","year":"2012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014\u20103820.2002.tb01412.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.9637"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201046422\u20102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.13191"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.14416"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/683119"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115104"},{"key":"e_1_2_9_17_1","first-page":"9","article-title":"A Review of Early Mortality Syndrome (EMS) in Great Lakes Salmonids: Relationship withThiamine Deficiency","volume":"28","author":"Fitzsimons J. D.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/faf.12816"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/fbaa015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2017.01.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2019.05.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.2000.00053.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815080115"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11160\u2010018\u20109538\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.15334"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1420\u20109101.1999.00044.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1577\/H03\u2010078.1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2015.06.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/arl080"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030484"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0308844"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.14213"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.3730"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1139\/f05\u2010210"},{"key":"e_1_2_9_35_1","first-page":"61","article-title":"The Baltic Salmon (\n                     Salmo salar\n                   L.): Its History, Present Siutation and Future","volume":"10","author":"Karlsson L.","year":"1994","journal-title":"Dana"},{"key":"e_1_2_9_36_1","first-page":"82","article-title":"Development of the M74 Syndrome in Wild Populations of Baltic Salmon (Salmo Sala) in Swedish Rivers","volume":"28","author":"Karlstr\u00f6m \u00d6.","year":"1999","journal-title":"Ambio"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.13517"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12040526"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/fishes10010016"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fss041"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2004.06.001"},{"key":"e_1_2_9_42_1","first-page":"79","article-title":"M74 Syndrome and Thiamine in Salmon Broodfish and Offspring","volume":"6","author":"Koski P.","year":"2001","journal-title":"Boreal Environment Research"},{"issue":"4","key":"e_1_2_9_43_1","first-page":"585","article-title":"Why Life Histories Are Diverse","volume":"54","author":"Kozlowski J.","year":"2006","journal-title":"Polish Journal of Ecology"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/692168"},{"key":"e_1_2_9_45_1","first-page":"82","volume-title":"Early Life Stage Mortality Syndrome in Fishes of the Great Lakes and Baltic Sea. Proceedings of the 126th Annual Meeting of the American Fisheries Society","author":"Lundstr\u00f6m J.","year":"1998"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227714"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2426011122"},{"key":"e_1_2_9_48_1","first-page":"92","article-title":"Mechanisms, Impacts, and Mitigation for Thiamine Deficiency and Early Life Stage Mortality in California's Central Valley Chinook Salmon","volume":"17","author":"Mantua N. J.","year":"2021","journal-title":"North Pacific Anadromous Fish Commission, Canada"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fsr156"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201013884\u20101"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0030\u20101299.2004.13012.x"},{"key":"e_1_2_9_52_1","volume-title":"Molecular Nutrition Vitamins","author":"Patel V. B.","year":"2020"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjfas\u20102022\u20100126"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396\u2010023\u201001379\u2010z"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10020156"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201044654\u2010x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1086\/677926"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00155\u201018"},{"key":"e_1_2_9_59_1","volume-title":"Applied Biopharmaceutics & Pharmacokinetics","author":"Shargel L.","year":"2016"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12272"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.12.023"},{"key":"e_1_2_9_62_1","volume-title":"The Evolution of Life Histories","author":"Stearns S. C.","year":"1992"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2017.11.006"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.2764"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2002.2255"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3094"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2012.06.080"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.15584"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.70478"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020482"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100706.2008.17036.x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmsc.2002.1200"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/fishes9020058"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.08.075"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/10236244.2021.1941942"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10152\u2010020\u201000542\u20109"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11160\u2010023\u201009818\u2010y"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf01073936"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1086\/282461"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0044\u20108486(94)90375\u20101"}],"container-title":["Ecology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.72339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:54:11Z","timestamp":1761785651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ece3.72339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":79,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ece3.72339"],"URL":"https:\/\/doi.org\/10.1002\/ece3.72339","archive":["Portico"],"relation":{},"ISSN":["2045-7758","2045-7758"],"issn-type":[{"value":"2045-7758","type":"print"},{"value":"2045-7758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72339"}}