{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:07:54Z","timestamp":1772118474473,"version":"3.50.1"},"reference-count":86,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ecology and Evolution"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Coloration is perhaps one of the most prominent adaptations for survival and reproduction of many taxa. Coloration is of particular importance for aposematic species, which rely on their coloring and patterning acting as a warning signal to deter predators. Most research has focused on the evolution of warning coloration by natural selection. However, little information is available for color mutants of aposematic species, particularly at the genomic level. Here, I compare the transcriptomes of albino mutant caterpillars of the aposematic wood tiger moth (\n                    <jats:italic>Arctia plantaginis<\/jats:italic>\n                    ) to those of their full sibs having their distinctive orange\u2010black warning coloration. The results showed &gt;290 differentially expressed genes genome\u2010wide. Genes involved in the immune system, structural constituents of cuticular, and immunity were mostly downregulated in the albino caterpillars. Surprisingly, higher expression was observed in core melanin genes from albino caterpillars, suggesting that melanin synthesis may be disrupted in terminal ends of the pathway during its final conversion. Taken together, these results suggest that caterpillar albinism may not be due to a depletion of melanin precursor genes. In contrast, the albino condition may result from the combination of faulty melanin conversion late in its synthesis and structural deficiencies in the cuticular preventing its deposition. The results are discussed in the context of how albinism may impact individuals of aposematic species in the wild.\n                  <\/jats:p>","DOI":"10.1002\/ece3.7581","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T03:53:57Z","timestamp":1619927637000},"page":"7507-7517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative transcriptomics of albino and warningly\u2010coloured caterpillars"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-1798","authenticated-orcid":false,"given":"Juan A.","family":"Galarza","sequence":"first","affiliation":[{"name":"Dpartment of Biological and Environmental Science University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_9_3_1","first-page":"4013","article-title":"Flavonoids: Chemistry, biochemistry and antioxidant activity","volume":"5","author":"Alzand K","year":"2012","journal-title":"Journal of Pharmacy Research"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201004\u20100496"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2009.10.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2012.00535.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17471-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.2302"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0333"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects4030320"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/zoo.10068"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti610"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a110208"},{"key":"e_1_2_9_15_1","volume-title":"Adaptive coloration in animals","author":"Cott H. B.","year":"1940"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan8433"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(80)90461-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11041"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1534\/g3.115.023655","article-title":"Major improvements to the heliconius melpomene genome assembly used to confirm 10 chromosome fusion events in 6 million years of butterfly evolution (vol 6, p. 695, 2016)","volume":"6","author":"Davey J. W.","year":"2016","journal-title":"G3\u2010Genes Genomes Genetics"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-017-0504-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2004.00319.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0352"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8312.2006.00611.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msq192"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-011-0380-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2013.03.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2010.00401.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.096388"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2017.03.008"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esm046"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2010.01.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbi.12513"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8059-5_10"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.42.1.611"},{"key":"e_1_2_9_36_1","volume-title":"factoextra: Extract and Visualize the Results of Multivariate Data Analyses","author":"Kassambara A."},{"key":"e_1_2_9_37_1","volume-title":"Mimicry, aposematism and related phenomena in animals and plants. Bibliography 1800\u20101990","author":"Komarek S.","year":"1998"},{"key":"e_1_2_9_38_1","first-page":"97","article-title":"Albinism and leucism among European Viperinae: A review","volume":"15","author":"Krecs\u00e1k L.","year":"2008","journal-title":"Russian Journal of Herpetology"},{"key":"e_1_2_9_39_1","first-page":"503","article-title":"Different frequencies of partial albinism in populations of alpine butterflies of different size and connectivity (Erebia: Nymphalidae, Satyrinae)","volume":"56","author":"Kuras T.","year":"2001","journal-title":"Biologia"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-2-r12"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2007.10.024"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2008.00561.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2010.01686.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/evo.13066"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.186684"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068059"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2311.2009.01137.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2005.07.011"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/11956860.1999.11682516"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12170"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1461-0248.2002.00362.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00709"},{"key":"e_1_2_9_55_1","first-page":"229","article-title":"Leucistic marbled salamanders (Ambystoma opacum) in Virginia","volume":"29","author":"Mitchell J. C.","year":"2002","journal-title":"Herpetological Review"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10682-011-9471-0"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12167"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/araa048"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmb.2016.04.005"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.12037"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2656.12169"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1999)13:2<99::AID-HUMU2>3.0.CO;2-C"},{"key":"e_1_2_9_63_1","first-page":"421","article-title":"A new case of complete albinism in a bat from Brazil","volume":"14","author":"Oliveira H. F. M.","year":"2008","journal-title":"Chiroptera Neotropical"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2312"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3186"},{"key":"e_1_2_9_66_1","volume-title":"Advances in insect physiology","author":"Pener M. P.","year":"2009"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1700"},{"key":"e_1_2_9_68_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2017"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.5772\/67107"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711-017-0349-7"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5347(00)01897-8"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_9_74_1","first-page":"149","article-title":"Biochemistry and biosynthesis of insect pigments","volume":"111","author":"Shamim G.","year":"2014","journal-title":"EJE"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2311.2007.00931.x"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.01.022"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2008.09.034"},{"key":"e_1_2_9_78_1","first-page":"228","article-title":"Insect immunity and its signalling: An overview","volume":"7","author":"Tsakas S.","year":"2010","journal-title":"Invertebrate Survival Journal"},{"key":"e_1_2_9_79_1","first-page":"19","article-title":"The mechanism of lethality of al\/al silkworm larvae","volume":"22","author":"Tsujita M.","year":"1971","journal-title":"Symposia Cell Biology"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks596"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2017.07.010"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-016-0052"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010889"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr002"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.053678"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13812"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.356"}],"container-title":["Ecology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.7581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ece3.7581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ece3.7581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:36:54Z","timestamp":1692743814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ece3.7581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":86,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ece3.7581"],"URL":"https:\/\/doi.org\/10.1002\/ece3.7581","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/336636","asserted-by":"object"}]},"ISSN":["2045-7758","2045-7758"],"issn-type":[{"value":"2045-7758","type":"print"},{"value":"2045-7758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}