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Here, we test the hypothesis that the North American colonization by <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> occurred via a series of founder events. We present findings on genetic diversity, structure, and demographic history using data from 70 <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> populations in North America that were genotyped at 12\u00a0microsatellite loci and\/or ~20,000\u00a0single nucleotide polymorphisms, the largest genetic study of the region to date. We find evidence consistent with colonization driven by serial founder effect (SFE), with Florida as the putative source for a series of westward invasions. This scenario was supported by (1) a decrease in the genetic diversity of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> populations moving west, (2) a correlation between pairwise genetic and geographic distances, and (3) demographic analysis based on allele frequencies. A few <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> populations on the west coast do not follow the general trend, likely due to a recent and distinct invasion history. We argue that SFE provides a helpful albeit simplified model for the movement of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic> across North America, with outlier populations warranting further investigation.<\/jats:p>","DOI":"10.1002\/ece3.8896","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T12:21:50Z","timestamp":1652444510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evidence for serial founder events during the colonization of North America by the yellow fever mosquito, <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-3397","authenticated-orcid":false,"given":"Evlyn","family":"Pless","sequence":"first","affiliation":[{"name":"Department of Ecology and Evolutionary Biology Yale University  New Haven Connecticut USA"},{"name":"Department of Anthropology University of California  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