{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:50:29Z","timestamp":1780059029941,"version":"3.54.0"},"reference-count":146,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sympathetic nervous system (SNS) overactivity is a risk factor for insulin resistance and cardiovascular disease (CVD). We evaluated the impact of bromocriptine\u2010QR, a dopamine\u2010agonist antidiabetes medication, on elevated resting heart rate (RHR) (a marker of SNS overactivity\u00a0in metabolic syndrome), blood pressure (BP) and the relationship between bromocriptine\u2010QR's effects on RHR and HbA1c in type 2 diabetes subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Subjects<\/jats:title><jats:p>RHR and BP changes were evaluated in this post hoc analysis of data from a randomized controlled trial in 1014 type 2 diabetes\u00a0subjects randomized to bromocriptine\u2010QR vs placebo added to standard therapy (diet\u00a0\u00b1\u00a0\u22642 oral antidiabetes medications) for 24\u00a0weeks without concomitant antihypertensive or antidiabetes medication changes, stratified by baseline RHR (bRHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In subjects with bRHR \u226570\u00a0beats\/min, bromocriptine\u2010QR vs placebo reduced RHR by \u22123.4 beats\/min and reduced BP (baseline 130\/79; systolic, diastolic, mean arterial BP reductions [mm\u00a0Hg]: \u22123.6 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02], \u22121.9 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.05], \u22122.5 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02]). RHR reductions increased with higher baseline HbA1c (bHbA1c) (\u22122.7 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03], \u22125 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002], \u22126.1 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002] with bHbA1c \u22647, &gt;7, \u22657.5%, respectively] in the bRHR \u226570 group and more so with bRHR \u226580 (\u22124.5 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07], \u22127.8 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015], \u22129.9 [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005]). Subjects with bRHR &lt;70 had no significant change in RHR or BP. With bHbA1c \u22657.5%, %HbA1c reductions with bromocriptine\u2010QR vs placebo were \u22120.50 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), \u22120.73 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and \u22121.22 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) with bRHR &lt;70, \u226570 and \u226580, respectively. With bRHR \u226570, the magnitude of bromocriptine\u2010QR\u2010induced RHR reduction was an independent predictor of bromocriptine\u2010QR's HbA1c lowering effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bromocriptine\u2010QR lowers elevated RHR with concurrent decrease in BP and hyperglycaemia. These findings suggest a potential sympatholytic mechanism contributing to bromocriptine\u2010QR's antidiabetes effect and potentially its previously demonstrated effect to reduce CVD events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.101","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T11:31:16Z","timestamp":1573644676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Circadian\u2010timed quick\u2010release bromocriptine lowers elevated resting heart rate in patients with type 2 diabetes mellitus"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-1215","authenticated-orcid":false,"given":"Bindu","family":"Chamarthi","sequence":"first","affiliation":[{"name":"VeroScience LLC Tiverton Rhode 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