{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:39:20Z","timestamp":1777163960080,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with NAFLD have a two\u2010fold increased risk of diabetes, and conversely, NAFLD affects up to 80% of patients with type 2 diabetes. Due to the co\u2010occurrence of both diseases and the lack of approved pharmacotherapy for NAFLD, the anti\u2010steatogenic potential of diabetes\u2010related drugs is being explored. In this study, we aim to monitor liver fat noninvasively during treatment with SGLT\u20102 inhibitors or GLP\u20101 analogues in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 39 patients (49% women, age 57.7\u00a0\u00b1\u00a010.9\u00a0years) with type 2 diabetes and hepatic steatosis (defined by controlled attenuation parameter [CAP] values \u2265\u00a0215\u00a0dB\/m) were observed for 6\u00a0months and routinely monitored with respect to hepatic fat contents and liver stiffness (VCTE); body composition (BIA); and blood biochemistry, including liver function tests (LFTs), serum lipids and glucose metabolism markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median liver fat contents were significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026) reduced by 9% in patients taking either SGLT\u20102 (n\u00a0=\u00a022) or GLP\u20101 (n\u00a0=\u00a017) for 6\u00a0months (absolute median CAP decrease: \u221232\u00a0dB\/m [\u221258 to 32\u00a0dB\/m]). In parallel, serum ALT and \u03b3\u2010GT activities decreased significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049, respectively). These improvements were accompanied by significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) changes to body weight and BMI (\u22122.5\u00a0\u00b1\u00a03.3\u00a0kg and \u22120.9\u00a0\u00b1\u00a01.2\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively) and glucose homeostasis, with significant reductions in HbA<jats:sub>1c<\/jats:sub> and fasting plasma glucose (FDG) (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Of note, significant reductions of intrahepatic lipid contents occured in patients receiving SGLT\u20102 inhibitors only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this real\u2010world observational evaluation of fatty liver monitored noninvasively in patients with type 2 diabetes treated with either SGLT2 or GLP\u20101, improvements in measures of hepatic steatosis, glucose and weight parameters were observed after 6\u00a0months, with significant reductions of intrahepatic lipid contents seen specifically in the SGLT2 subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.131","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T18:00:53Z","timestamp":1589306453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Noninvasive monitoring of liver fat during treatment with GLP\u20101 analogues and SGLT\u20102 inhibitors in a real\u2010world 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