{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:03:32Z","timestamp":1774321412791,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypopituitarism is a recognized sequela of traumatic brain injury (TBI) and may worsen the quality of life (QoL) in survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the prevalence of post\u2010traumatic hypopituitarism (PTHP) and growth hormone deficiency (GHD), and determine their correlation with QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Survivors of moderate to severe TBI were recruited from two Algerian centres. At 3 and 12\u00a0months, pituitary function was evaluated using insulin tolerance test (ITT), QoL by growth hormone deficiency in adults\u2019 questionnaire (QoL\u2010AGHDA), and 36\u2010item short\u2010form (SF\u201036) health survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 133 (M: 128; F: 5) patients aged 18\u201065\u00a0years, PTHP and GHD were present at 3 and 12\u00a0months in 59 (44.4%) and 23 (17.29%), 41\/116 (35.3%) and 18 (15.5%). Thirteen patients with GHD at 3\u00a0months tested normally at 12\u00a0months, while 9 had become GHD at 12\u00a0months. At 3 and 12\u00a0months, peak cortisol was\u00a0&lt;\u00a0500\u00a0nmol\/L) in 39 (29.3%) and 29 (25%) patients, but &lt;300\u00a0nmol\/L in only five and seven. Prevalence for gonadotrophin deficiency was 6.8\/8.6%, hypo\u2010 and hyperprolactinaemia 6.8\/3.8% and 5.2\/8.6%, and thyrotrophin deficiency 1.5\/0.9%. Mean scores for QoL\u2010AGHDA were higher in patients with PTHP at 3 and 12\u00a0months: 7.07 vs 3.62 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and in patients with GHD at 12\u00a0months: 8.72 vs 4.09 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015). Mean SF\u201036 scores were significantly lower for PTHP at 3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevalence of PTHP and GHD changes with time. AGHDA measures QoL in GHD more specifically than SF\u201036. Full pituitary evaluation and QoL\u2010AGHDA 12\u00a0months after TBI are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.146","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T14:49:37Z","timestamp":1591368577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of hypopituitarism and quality of life in survivors of post\u2010traumatic brain injury"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-6076","authenticated-orcid":false,"given":"Meriem","family":"Bensalah","sequence":"first","affiliation":[{"name":"Endocrinology Unit Central Hospital of Army Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Glasgow University School of Medicine Glasgow 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