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This systematic review aimed to evaluate the efficacy of GLP\u20101 RAs in the management of NAFLD, the degree of heterogeneity in trial design and the robustness of conclusions drawn from these clinical trials. We searched publication databases and clinical trial registries through 2 November 2019 for clinical trials with NAFLD. We evaluated improvements in histological findings, noninvasive markers of hepatic steatosis, inflammation, and fibrosis, insulin resistance and anthropometric measures. Our final analysis included 24 clinical trials, comprising 6313 participants with a mean duration of 37\u00a0weeks. Four clinical trials, including RCT (n\u00a0=\u00a01), single\u2010arm studies (n\u00a0=\u00a02) and case series studies (n\u00a0=\u00a01), used biopsy\u2010confirmed liver histological change as their end\u2010points. The remaining studies (n\u00a0=\u00a020) used surrogate end\u2010points. GLP\u20101 RAs were effective for the improvement in hepatic inflammation, hepatic steatosis and fibrosis. More importantly, GLP\u20101 RAs showed promise in improving the histological features of NASH. In addition, 8 ongoing trials were identified. In this systematic review of published and ongoing clinical trials of the efficacy of GLP\u20101RAs for NAFLD, we found that GLP\u20101 RAs are effective for hepatic steatosis and inflammation, with the potential to reverse fibrosis. Further prospective studies of sufficient duration using histological end\u2010points are needed to fully assess the efficacy of GLP\u20101 RAs in the management of NAFLD.<\/jats:p>","DOI":"10.1002\/edm2.163","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T05:26:28Z","timestamp":1591939588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) for the management of nonalcoholic fatty liver disease (NAFLD): A systematic review"],"prefix":"10.1002","volume":"3","author":[{"given":"Xiaodan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Endocrinology China\u2010Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery The 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