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Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Melatonin\u2010proficient (C3H\u2010f<jats:sup>+\/+<\/jats:sup> or WT) and melatonin receptor type 1 knockout (MT<jats:sub>1<\/jats:sub> KO) male and female mice were phase\u2010advanced (6\u00a0hours) once a week for 6\u00a0weeks. Every week, we measured weight, food intake and basal glucose levels. At the end of the experiment, we sacrificed the animals and measured the blood's plasma for lipids profile (total lipids, phospholipids, triglycerides and total cholesterol), metabolic hormones profiles (ghrelin, leptin, insulin, glucagon, glucagon\u2010like\u2010peptide and resistin) and the body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Environmental circadian disruption (ECD) did not produce any significant effects in C3H\u2010f<jats:sup>+\/+<\/jats:sup>, while it increased lipids profile in MT<jats:sub>1<\/jats:sub> KO with the significant increase observed in total lipids and triglycerides. For metabolic hormones profile, ECD decreased plasma ghrelin and increased plasma insulin in MT<jats:sub>1<\/jats:sub> KO females. Under control condition, MT<jats:sub>1<\/jats:sub> KO females have significantly different body weight, fat mass, total lipids and total cholesterol than the control C3H\u2010f<jats:sup>+\/+<\/jats:sup> females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that melatonin\u2010proficient mice are not affected by ECD. When the MT<jats:sub>1<\/jats:sub> receptors are removed, ECD induced dyslipidaemia in males and females with females experiencing the most adverse effect. Overall, our data demonstrate that MT<jats:sub>1<\/jats:sub> signalling is an essential modulator of lipid and metabolic homeostasis during ECD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.171","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:24:34Z","timestamp":1601324674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption"],"prefix":"10.1002","volume":"4","author":[{"given":"Cynthia","family":"Tchio","sequence":"first","affiliation":[{"name":"Circadian Rhythms and Sleep Disorders Program Neuroscience Institute Atlanta GA USA"},{"name":"Department of Pharmacology and Toxicology Morehouse School of Medicine Neuroscience Institute Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenkichi","family":"Baba","sequence":"additional","affiliation":[{"name":"Circadian Rhythms and Sleep Disorders Program Neuroscience Institute Atlanta GA USA"},{"name":"Department of Pharmacology and Toxicology Morehouse School of Medicine Neuroscience Institute Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Piccione","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicine Veterinaria Universita di Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3645-4533","authenticated-orcid":false,"given":"Gianluca","family":"Tosini","sequence":"additional","affiliation":[{"name":"Circadian Rhythms and Sleep Disorders Program Neuroscience Institute Atlanta GA USA"},{"name":"Department of Pharmacology and Toxicology Morehouse School of Medicine Neuroscience Institute Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0581-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.13.12.0390"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.3.1054-1060.2003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1211"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.12.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80350-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13536"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00230.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.667859"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12137"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00488"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12257"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.24"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12462"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12580"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.058"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001026"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12743"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018375108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.08.059"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00935"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3941912"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1989.tb00667.x"},{"key":"e_1_2_9_25_1","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"1996"},{"key":"e_1_2_9_26_1","volume-title":"Guide Laboratory Animals for the Care and Use of Eighth Edition Committee for the Update of the Guide for the Care and Use of Laboratory Animals Institute for Laboratory Animal Research Division on Earth and Life Studies","author":"NIH OD, OER, & OLAW","year":"2011"},{"key":"e_1_2_9_27_1","unstructured":"OLAW.PHS Policy on Humane Care and Use of Laboratory Animals; n.d.https:\/\/olaw.nih.gov\/policies\u2010laws\/phs\u2010policy.htm. 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