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This systematic review was performed to summarize published data about risk factors for the diabetic foot (DF) syndrome in order to improve the identification of high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Six electronic databases were searched for publications up to August 2019 using predefined stringent inclusion and exclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 9,476 identified articles, 31 articles from 28 different study populations fulfilled the criteria for our evaluation. The overall quality of the studies was good, and the risk of bias was low. There was large heterogeneity among the studies concerning study protocols and patient populations analysed. A total of 79 risk factors were analysed within this review. The majority of studies described a consistently positive association with different outcomes of interest related to DF for gender, peripheral neuropathy, retinopathy, nephropathy, poor glycaemic control, insulin use, duration of diabetes, smoking and height. For age, hypertension, dyslipidaemia and body mass index, the results remain inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A most up\u2010to\u2010date literature review resulted in glycaemic control and smoking as the only amenable risk factors with a consistently positive association for DF. Due to the high personal and financial burden associated with DF and the large heterogeneity among included studies, additional longitudinal studies in large patient populations are necessary to identify more modifiable risk factors that can be used in the prediction and prevention of DF complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.175","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:05:59Z","timestamp":1598601959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Risk factors for diabetic foot complications in type 2 diabetes\u2014A systematic review"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-946X","authenticated-orcid":false,"given":"Sophia","family":"Rossboth","sequence":"first","affiliation":[{"name":"Medical Informatics and Technology Public Health, Health Services Research and Health Technology Assessment UMIT \u2010 University for Health Sciences Hall in Troll Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Lechleitner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Hochzirl Zirl Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Oberaigner","sequence":"additional","affiliation":[{"name":"Medical Informatics and Technology Public Health, Health Services Research and Health Technology Assessment UMIT \u2010 University for Health Sciences Hall in Troll Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2019"},{"key":"e_1_2_11_3_1","volume-title":"Global Report on Diabetes","author":"World Health Organization","year":"2016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2011"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"e3268","article-title":"Definitions and criteria for diabetic foot disease","volume":"36","author":"Netten JJ","year":"2019","journal-title":"Diabetes Metab Res Rev"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470846585.ch28"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03698.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03279.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199611)13:11<967::AID-DIA266>3.0.CO;2-K"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2145"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2031"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.37"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2017.1305891"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2319"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-S002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3073"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1064"},{"key":"e_1_2_11_23_1","unstructured":"WellsGA SheaB O\u2019ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. 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