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The pathophysiology of paediatric NAFLD is complex and multifactorial, driven by an interaction of environmental and genetic factors. Once developed, NAFLD in childhood is associated with type 2 diabetes, hypertension, increased cardiovascular disease risk, and end\u2010stage liver disease. This predicts an increased burden of morbidity and mortality in adolescents and young adults. Early screening and diagnosis are therefore crucial, and the development of noninvasive biomarkers remains an active area of investigation. Currently, treatment strategies are focused on lifestyle changes, but there is also research interest in pharmacological and surgical options. In the transition from paediatric to adult care, there are several potential challenges\/barriers to treatment and research is needed to understand how best to support patients during this time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our understanding of the epidemiology and pathophysiology of paediatric NAFLD has increased considerably over recent decades, but several critical knowledge gaps remain and must be addressed in order to better mitigate the short\u2010term and long\u2010term risks of youth\u2010onset NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.184","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:18:52Z","timestamp":1600402732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Perspectives on youth\u2010onset nonalcoholic fatty liver 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