{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:30:16Z","timestamp":1790350216612,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002655","name":"Beckman Coulter Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Anti\u2010M\u00fcllerian Hormone (\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      ) concentration is high at birth in males, demonstrating the presence of functional testicular tissue in the prepubertal period, and acting as a useful marker in the investigation of paediatric reproductive disorders.\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      also provides a tool in the investigation of female virilization, premature ovarian failure and polycystic ovarian syndrome in childhood. Robust, assay\u2010specific paediatric\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      reference intervals are therefore required for clinical interpretation of results. The aim of this study was to derive age\u2010specific\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      reference intervals for males and females aged 0\u201018\u00a0years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Patients<\/jats:title>\n                    <jats:p>\n                      Plasma samples were obtained from patients at Royal Manchester Children's Hospital and analysed for\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      using the automated Beckman Coulter Access AMH Assay. Patients under investigation for paediatric reproductive or endocrine disorders were excluded from the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Seven hundred and 2 patient plasma samples (465 male, 237 female) were subject to\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      measurement, and results were analysed in order to derive continuous and discrete reference intervals for the paediatric age range.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clear discrimination between male and female\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      results was evident in the prepubertal age range, with some overlap between the genders following pubertal onset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We have derived age\u2010related reference intervals for plasma\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      in the paediatric age range (0\u201018\u00a0years) using the automated Beckman Coulter Access\n                      <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                      assay which will aid in the investigation of paediatric endocrine disorders such as disorders of sexual development.\n                    <\/jats:p>\n                  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