{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:07:46Z","timestamp":1772118466226,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Severe COVID\u201019 has been anecdotally associated with high insulin requirements. It has been proposed that this may be driven by a direct diabetogenic effect of the virus that is unique to SARS\u2010CoV\u20102, but evidence to support this is limited. To explore this, we compared insulin requirements in patients with severe COVID\u201019 and non\u2010COVID\u201019 viral pneumonitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study of patients with severe COVID\u201019 admitted to our intensive care unit between March and June 2020. A historical control cohort of non\u2010COVID\u201019 viral pneumonitis patients was identified from routinely collected audit data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Insulin requirements were similar in patients with COVID\u201019 and non\u2010COVID\u201019 viral pneumonitis after adjustment for pre\u2010existing diabetes and severity of respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single\u2010centre study, we could not find evidence of a unique diabetogenic effect of COVID\u201019. We suggest that high insulin requirements in this disease relate to its propensity to cause severe respiratory failure in patients with pre\u2010existing metabolic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/edm2.228","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T23:37:28Z","timestamp":1613259448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The excess insulin requirement in severe COVID\u201019 compared to non\u2010COVID\u201019 viral pneumonitis is related to the severity of respiratory failure and pre\u2010existing diabetes"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-4350","authenticated-orcid":false,"given":"Sam M.","family":"Lockhart","sequence":"first","affiliation":[{"name":"MRC Metabolic Diseases Unit Wellcome Trust\u2010Medical Research Council Institute of Metabolic Science University of Cambridge Cambridge UK"},{"name":"Wolfson Diabetes and Endocrinology Clinic Cambridge University Hospital NHS Foundation Trust Cambridge UK"},{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Griffiths","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Petrisor","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammara","family":"Usman","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Calvo\u2010Latorre","sequence":"additional","affiliation":[{"name":"Wolfson Diabetes and Endocrinology Clinic Cambridge University Hospital NHS Foundation Trust Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Heales","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishakha","family":"Bansiya","sequence":"additional","affiliation":[{"name":"Wolfson Diabetes and Endocrinology Clinic Cambridge University Hospital NHS Foundation Trust Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razeen","family":"Mahroof","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-3216","authenticated-orcid":false,"given":"Andrew","family":"Conway Morris","sequence":"additional","affiliation":[{"name":"John Farman Intensive Care Unit Addenbrooke\u2019s Hospital Cambridge UK"},{"name":"University Division of Anaesthesia Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2018688"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30152-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14288"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30234-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05164-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296820924469"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108374"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113635"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435800.2020.1856865"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.11.015"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"133","article-title":"Study protocol and statistical analysis plan for the Liberal Glucose Control in Critically Ill Patients with Pre\u2010existing Type 2 Diabetes (LUCID) trial","volume":"22","author":"Poole AP","year":"2020","journal-title":"Crit Care Resusc"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60553-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci20-0044"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.13445"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1551"}],"container-title":["Endocrinology, Diabetes &amp; 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