{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:05:52Z","timestamp":1762445152174,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Longitudinal data on progression, complications, and management of type 2 diabetes mellitus (T2DM) across India are scarce. LANDMARC (CTRI\/2017\/05\/008452), the first <jats:italic>pan<\/jats:italic>\u2010India, longitudinal, prospective, observational study, aims to understand the management and real\u2010world outcomes of T2DM over 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults (\u226525 to \u226460\u00a0years old at T2DM diagnosis; diabetes duration \u22652\u00a0years at enrollment; controlled\/uncontrolled on \u22652 anti\u2010diabetic agents) were enrolled. Baseline characteristics were analyzed using descriptive statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6279 recruited participants, 6236 were eligible for baseline assessment (56.6% [<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a03528\/6236] men; mean\u00a0\u00b1\u00a0SD age: 52.1\u00a0\u00b1\u00a09.2\u00a0years, diabetes duration: 8.6\u00a0\u00b1\u00a05.6\u00a0years). mean\u00a0\u00b1\u00a0SD HbA1c, fasting plasma glucose, and postprandial glucose values were 64\u00a0\u00b1\u00a017\u00a0mmol\/mol (8.1\u00a0\u00b1\u00a01.6%), 142.8\u00a0\u00b1\u00a050.4\u00a0mg\/dl, and 205.7\u00a0\u00b1\u00a072.3\u00a0mg\/dl, respectively. Only 25.1% (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a01122\/6236) participants had controlled glycemia (HbA1c\u00a0&lt;\u00a053\u00a0mmol\/mol, &lt;7%). Macrovascular and microvascular complications were prevalent in 2.3% (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a0145\/6236) and 14.5% (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a0902\/6236) participants, respectively. Among those with complications, non\u2010fatal myocardial infarction (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a074\/145, 51.0%) and neuropathy (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a0737\/902, 81.7%) were the most reported macrovascular and microvascular complication, respectively. Hypertension (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a02566\/3281, 78.2%) and dyslipidemia (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a01635\/3281, 49.8%) were the most reported cardiovascular risks. Majority (74.5%; <jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a04643\/6236) were taking oral anti\u2010diabetic drugs (OADs) only, while 24.4% (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a01522\/6236) participants were taking OADs+insulin. Biguanides (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a05796\/6236, 92.9%) and sulfonylureas (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a04757\/6236, 76.3%) were the most reported OADs. Basal (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a0837\/6236, 13.4%) and premix (<jats:italic>n<\/jats:italic>\/<jats:italic>N<\/jats:italic>\u00a0=\u00a0684\/6236, 11.0%) insulins were the most reported insulins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline data from LANDMARC help understand the clinical\/medical profile of study participants and underscore the extent of suboptimal glycemic control and prevalence of associated complications in a vast majority of Indians with T2DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.231","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T14:29:44Z","timestamp":1612880984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Baseline characteristics of participants in the LANDMARC trial: A 3\u2010year, <i>pan<\/i>\u2010india, prospective, longitudinal study to assess management and real\u2010world outcomes of diabetes mellitus"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-1885","authenticated-orcid":false,"given":"Ashok K.","family":"Das","sequence":"first","affiliation":[{"name":"Pondicherry Institute of Medical Sciences (PIMS Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrish","family":"Mithal","sequence":"additional","affiliation":[{"name":"Medanta \u2010 The Medicity Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Joshi","sequence":"additional","affiliation":[{"name":"Lilavati Hospital Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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