{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:32:07Z","timestamp":1770748327105,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sulfonylureas and dipeptidyl peptidase\u20104 inhibitors have a multidirectional effect on pancreatic cells. We aimed to evaluate the effects of these drugs on \u03b2\u2010 and \u03b1\u2010cells in rats aged 12\u00a0months with type 2 diabetes mellitus when administered in combination with various sulfonylureas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Streptozotocin\u2010nicotinamide induced type 2 diabetes mellitus was induced in rats aged 12\u00a0months. Animals received the sulfonylureas gliclazide or glibenclamide for 24\u00a0weeks alone or in combination with the dipeptidyl peptidase\u20104 inhibitor vildagliptin or vildagliptin monotherapy. Blood glucose and animal weights were measured before and during the experiment. The oral glucose tolerance test was conducted before therapy initiation. Immunohistochemical analyses were conducted after the end of the experiment using glucagon and insulin antibodies. The total volumes of \u03b1 and \u03b2 cells were estimated in relation to the volume of the pancreatic islets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total volumes of \u03b2\u2010cells did not differ between the sulfonylurea group and the untreated type 2 diabetes mellitus group. The addition of dipeptidyl peptidase\u20104 inhibitors to sulfonylureas normalized the total volumes of \u03b2 cells. The total volumes of \u03b1\u2010cells in the gliclazide group and combination of gliclazide with dipeptidyl peptidase\u20104 inhibitor was comparable to that in the control group of intact animals, in contrast with the glibenclamide group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of vildagliptin to both sulfonylureas contributed to the normalisation of \u03b2\u2010cells number. Normalisation of the total volumes of \u03b1\u2010cells was observed with gliclazide therapy and combination of gliclazide with dipeptidyl peptidase\u20104 inhibitor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.238","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T05:06:15Z","timestamp":1616130375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dynamics of total volume of pancreatic \u03b1\u2010 and \u03b2 \u2010cells under the influence sulfonylureas and their combination with dipeptidyl peptidase\u20104 inhibitors"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-8650","authenticated-orcid":false,"given":"Tuchina","family":"Taisiia Pavlovna","sequence":"first","affiliation":[{"name":"Almazov National Medical Research Centre Saint Petersburg 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