{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:16:41Z","timestamp":1790201801799,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Endocrino Diabet &amp; Metabol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Late\u2010night salivary cortisol (LSaC) and 24\u2010h urinary free cortisol measurement, and overnight 1\u2010mg dexamethasone suppression test (1\u00a0mg\u2010DST) are the first\u2010line screening tests recommended for Cushing's syndrome. Through elevations in the level of cortisol\u2010binding globulin, oral contraceptive agents lead to increases in the total plasma cortisol concentration, yielding false\u2010positive 1\u00a0mg\u2010DST results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the accuracy of the overnight 1\u2010mg DST and two\u2010day low\u2010dose DST (2d\u2010DST) in female volunteers taking combined oestrogen\u2010progestin oral contraceptives (COCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study enrolled 30 healthy participants. Their plasma cortisol response levels were compared after the 1\u2010mg DST and 2d\u2010DST and classified into three categories: normal (\u226450\u00a0nmol\/L), doubtful (51\u2013138\u00a0nmol\/L) and abnormal (&gt;138\u00a0nmol\/L). Salivary cortisol was also measured at late night and after the DSTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the 1\u2010mg DST and 2d\u2010DST, the plasma cortisol concentrations decreased to a median of 69\u00a0nmol\/L and 37\u00a0nmol\/L, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). A statistically significant higher proportion of unclear or abnormal results were observed after the 1\u2010mg DST (63%) than after the 2d\u2010DST (27%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). None of the values were &gt;138\u00a0nmol\/L after the 2d\u2010DST, while 11% of them were abnormal after the 1\u2010mg DST (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.25). No LSaC value was abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that, when late\u2010night salivary cortisol is not available, the 2d\u2010DST could be a better screening option than the 1\u2010mg DST for women taking oral contraceptive agents who are reluctant to stop them. This finding requires confirmation in those with a suspicion of hypercortisolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/edm2.255","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T12:10:55Z","timestamp":1622031055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Two\u2010day low\u2010dose dexamethasone suppression test more accurate than overnight 1\u2010mg in women taking oral contraceptives"],"prefix":"10.1002","volume":"4","author":[{"given":"Tiphaine","family":"Carton","sequence":"first","affiliation":[{"name":"Department of Endocrinology Cliniques Universitaires de Bruxelles H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Laboratoire Hospitalier Universitaire de Bruxelles (LHUB\u2010ULB) Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Laboratoire Hospitalier Universitaire de Bruxelles (LHUB\u2010ULB) Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Bouziotis","sequence":"additional","affiliation":[{"name":"Service de la Recherche Biom\u00e9dicale Cliniques Universitaires de Bruxelles H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Corvilain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cliniques Universitaires de Bruxelles H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5992-2486","authenticated-orcid":false,"given":"Natacha","family":"Driessens","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cliniques Universitaires de Bruxelles H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0666"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0467"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2722"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70115-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2018.03.013"},{"key":"e_1_2_9_7_1","first-page":"396","article-title":"Cardiovascular 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